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三叉神经痛三重穿刺:一项随机临床试验。

Triple Puncture for Primary Trigeminal Neuralgia: A Randomized Clinical Trial.

机构信息

Department of Physical Medicine and Rehabilitation, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, 430015, China.

Sector of P.E., China University of Geosciences, Wuhan, 430074, China.

出版信息

Curr Med Sci. 2019 Aug;39(4):638-644. doi: 10.1007/s11596-019-2085-4. Epub 2019 Jul 25.

DOI:10.1007/s11596-019-2085-4
PMID:31347002
Abstract

To evaluate the effect of triple puncture on primary trigeminal neuralgia (pTN), 64 patients with pTN were randomly assigned to two groups: treatment group and control group. The participants in the treatment group received triple puncture treatment of 6 times per week for 4 weeks, and those in control group were given carbamazepine (300-600 mg per day) for at least 1 month. Before and after treatment, the primary outcomes including the total efficiency rate and the VAS pain scores, and the secondary outcomes including the frequency of pain attack and adverse events were observed. Sixty-two participants finished the study (33 in treatment group and 29 in control group individually). After treatment, the symptoms (mainly pain) of the two groups were alleviated. The total efficiency rate in the treatment group and control group was 90.9% and 75.9% respectively. The VAS pain scores and frequency of pain attack were significantly reduced in the treatment group as compared with the control group (P<0.05). The incidence of adverse events in the treatment group and control group was 9.1% and 24.1% respectively. It can be inferred that triple puncture can effectively improve the quality of life of patients with pTN and has less side effects.

摘要

为了评估三叉神经痛(pTN)的三重穿刺效果,将 64 例 pTN 患者随机分为两组:治疗组和对照组。治疗组每周接受 6 次三重穿刺治疗,共 4 周,对照组则至少服用卡马西平(300-600mg/天)1 个月。在治疗前后,观察主要结局指标(总有效率和 VAS 疼痛评分)和次要结局指标(疼痛发作频率和不良反应)。62 名参与者完成了研究(治疗组 33 名,对照组 29 名)。治疗后,两组症状(主要是疼痛)均有所缓解。治疗组的总有效率为 90.9%,对照组为 75.9%。与对照组相比,治疗组的 VAS 疼痛评分和疼痛发作频率明显降低(P<0.05)。治疗组和对照组不良反应的发生率分别为 9.1%和 24.1%。可以推断三重穿刺能有效提高 pTN 患者的生活质量,且副作用较少。

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