Advanced Research Centre for Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.
Adv Exp Med Biol. 2019;1140:685-701. doi: 10.1007/978-3-030-15950-4_41.
An important and well-designed solution to overcome some of the problems associated with new drugs is provided by the molecular encapsulation of the drugs in the cyclodextrins (CDs) cavity, yielding corresponding inclusion complexes (ICs). These types of non-covalent complexes are of current interest to the pharmaceutical industry, as they improve the solubility, stability and bioavailability of the guest molecules. This review highlights several methods for cyclodextrin ICs preparation and characterization, focusing mostly on the mass spectrometry (MS) studies that have been used for the detection of noncovalent interactions of CDs inclusion complexes and binding selectivity of guest molecules with CDs. Furthermore, the MS investigations of several ICs of the CD with antifungal, antioxidants or fluorescent dyes are presented in greater details, pointing out the difficulties overcome in the analysis of this type of compounds.
一种重要且设计精良的解决方案，可以克服与新药相关的一些问题，是将药物分子封装在环糊精（CDs）腔中，形成相应的包合物（ICs）。这些类型的非共价复合物是制药行业目前关注的焦点，因为它们可以提高客体分子的溶解度、稳定性和生物利用度。本文重点介绍了几种环糊精 ICs 的制备和表征方法，主要集中在质谱（MS）研究上，这些研究用于检测 CD 包合物的非共价相互作用和客体分子与 CD 的结合选择性。此外，还详细介绍了 CD 与抗真菌、抗氧化剂或荧光染料的几种 IC 的 MS 研究，指出了在分析这类化合物时所克服的困难。
