Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
National Institute for Public Health and the Environment (RIVM), Centre for Nutrition, Prevention and Health Services Research, Bilthoven, The Netherlands.
Pharmacoeconomics. 2019 Nov;37(11):1305-1312. doi: 10.1007/s40273-019-00825-1.
Transparency in health economic decision modelling is important for engendering confidence in the models and in the reliability of model-based cost-effectiveness analyses. The Mount Hood Diabetes Challenge Network has taken a lead in promoting transparency through validation with biennial conferences in which diabetes modelling groups meet to compare simulated outcomes of pre-specified scenarios often based on the results of pivotal clinical trials. Model registration is a potential method for promoting transparency, while also reducing the duplication of effort. An important network initiative is the ongoing construction of a diabetes model registry (https://www.mthooddiabeteschallenge.com). Following the 2012 International Society for Pharmacoeconomics and Outcomes Research and the Society of Medical Decision Making (ISPOR-SMDM) guidelines, we recommend that modelling groups provide technical and non-technical documentation sufficient to enable model reproduction, but not necessarily provide the model code. We also request that modelling groups upload documentation on the methods and outcomes of validation efforts, and run reference case simulations so that model outcomes can be compared. In this paper, we discuss conflicting definitions of transparency in health economic modelling, and describe the ongoing development of a registry of economic models for diabetes through the Mount Hood Diabetes Challenge Network, its objectives and potential further developments, and highlight the challenges in its construction and maintenance. The support of key stakeholders such as decision-making bodies and journals is key to ensuring the success of this and other registries. In the absence of public funding, the development of a network of modellers is of huge value in enhancing transparency, whether through registries or other means.
健康经济决策模型的透明度对于建立对模型和基于模型的成本效益分析的可靠性的信心非常重要。胡德山糖尿病挑战赛网络通过两年一度的会议，在促进透明度方面发挥了主导作用，这些会议让糖尿病建模小组聚集在一起，比较预先指定的情况下的模拟结果，这些情况通常基于关键临床试验的结果。模型注册是促进透明度的一种潜在方法，同时也减少了重复工作。一个重要的网络倡议是正在进行的糖尿病模型注册（https://www.mthooddiabeteschallenge.com）。我们遵循国际药物经济学与结果研究学会和医学决策制定学会（ISPOR-SMDM）的 2012 年指南，建议建模小组提供足够的技术和非技术文档，以实现模型复制，但不一定提供模型代码。我们还要求建模小组上传验证工作的方法和结果文档，并运行参考案例模拟，以便比较模型结果。在本文中，我们讨论了健康经济建模中透明度的不同定义，并描述了通过胡德山糖尿病挑战赛网络正在开发的糖尿病经济模型注册，以及其目标和潜在的进一步发展，并强调了其构建和维护所面临的挑战。关键利益相关者（如决策机构和期刊）的支持是确保该注册及其它注册成功的关键。在缺乏公共资金的情况下，建立建模人员网络对于提高透明度非常有价值，无论是通过注册还是其他方式。
