Johnson Mahlon D, Hussain Ali
Clin Neuropathol. 2019 Sep/Oct;38(5):238-244. doi: 10.5414/NP301139.
Due to their rarity, the natural history and imaging of myxoid meningiomas are not completely characterized. We analyzed clinical, imaging, and pathologic features of myxoid meningioma seen neurosurgically or in consultation between 1999 and 2018.
Archival material was searched for meningiomas designated "myxoid meningioma" at Vanderbilt University School of Medicine (1997 - 2004) and the University of Rochester School of Medicine and Dentistry (1994 - 2018).
Our cases were predominantly in females and presented with a slow progression of symptoms. Each tumor was in the hemispheres. Magnetic resonance imaging (MRI) found most were hyperintense on T2-weighted images. Each meningioma had foci of limited meningothelial amongst extensive myxoid histology with Alcian-blue-staining stroma and EMA-immunoreactive cells.
Myxoid meningiomas present with atypical imaging and histologic characteristics but are not truly metaplastic, i.e., are not differentiated to a different cell type.
由于黏液样脑膜瘤较为罕见，其自然病史和影像学表现尚未完全明确。我们分析了1999年至2018年间经神经外科手术或会诊的黏液样脑膜瘤的临床、影像学和病理特征。
在范德比尔特大学医学院（1997 - 2004年）和罗切斯特大学医学与牙科学院（1994 - 2018年）检索标记为“黏液样脑膜瘤”的存档材料。
我们的病例主要为女性，症状进展缓慢。每个肿瘤均位于大脑半球。磁共振成像（MRI）显示大多数肿瘤在T2加权图像上呈高信号。每个脑膜瘤在广泛的黏液样组织学中均有局限性脑膜上皮细胞灶，伴有阿尔辛蓝染色的基质和EMA免疫反应性细胞。
黏液样脑膜瘤具有非典型的影像学和组织学特征，但并非真正的化生，即未分化为不同的细胞类型。
