From the Medical Imaging Centre, Departments of Radiology, Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Clin Nucl Med. 2020 Jan;45(1):e32-e35. doi: 10.1097/RLU.0000000000002750.
Ga-PSMA PET/CT has emerged as a highly promising diagnostic method for the evaluation of prostate cancer. Although it is increasingly recognized that its specificity is imperfect, data on false-negatives in the prostate have been underreported. We present 3 cases with false-negatives for local (recurrent) prostate cancer on Ga-PSMA PET/CT, using multiparametric MRI and histopathology as reference standard. Metal artifact of prostate gold markers placed for external beam radiation therapy, low level of PSMA uptake, and bladder spillover are potential causes of misinterpretation. Awareness of these diagnostic pitfalls may improve Ga-PSMA PET/CT interpretation.
镓-PSMA PET/CT 已成为评估前列腺癌的一种极有前途的诊断方法。尽管人们越来越认识到其特异性并不完美，但前列腺癌假阴性的数据报道较少。我们报告了 3 例 Ga-PSMA PET/CT 前列腺局部（复发性）癌假阴性病例，以多参数 MRI 和组织病理学为参考标准。前列腺金标记物用于外照射放射治疗的金属伪影、PSMA 摄取水平低和膀胱溢出是导致误诊的潜在原因。了解这些诊断陷阱可能会改善 Ga-PSMA PET/CT 的解读。
