非酒精性脂肪性肝病中红细胞分布宽度与血小板比值和肝纤维化的关系：一项横断面研究。
Association between red cell distribution width-to-platelet ratio and hepatic fibrosis in nonalcoholic fatty liver disease: A cross-sectional study.
作者信息
Zhou Wen-Jie, Yang Jing, Zhang Ge, Hu Zheng-Qiang, Jiang Yong-Mei, Yu Fan
机构信息
Department of Laboratory Medicine, West China Second University Hospital, Sichuan University.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
出版信息
Medicine (Baltimore). 2019 Jul;98(30):e16565. doi: 10.1097/MD.0000000000016565.
BACKGROUND
We aimed to assess the association between red cell distribution width-to-platelet ratio (RPR) and hepatic fibrosis in nonalcoholic fatty liver disease.
METHODS
The 388 subjects fulfilling the diagnostic criteria of Nonalcoholic fatty liver disease (NAFLD) were enrolled in this cross-sectional study. Red cell distribution, platelet, and other clinical and laboratory parameters were measured.
RESULTS
NAFLD patients with advanced fibrosis had significantly higher RPR than those without fibrosis (P < .001). Spearman correlation analysis showed that RPR were significantly correlated with age, sex, creatinine, hemoglobin, white blood cell, and advanced fibrosis (all with P < .05). Multivariate logistic regression analysis showed that RPR was an independent factor predicting advanced fibrosis (fibrosis-4 calculator ≥1.3) in NAFLD patients (OR: 5.718, 95%CI: 3.326-9.830, P < .001).
CONCLUSIONS
Our findings suggested that RPR were significantly associated with advanced fibrosis in nonalcoholic fatty liver disease patients.
背景
我们旨在评估非酒精性脂肪性肝病中红细胞分布宽度与血小板比值（RPR）与肝纤维化之间的关联。
方法
本横断面研究纳入了388名符合非酒精性脂肪性肝病（NAFLD）诊断标准的受试者。测量了红细胞分布、血小板以及其他临床和实验室参数。
结果
晚期纤维化的NAFLD患者的RPR显著高于无纤维化患者（P<0.001）。Spearman相关性分析显示，RPR与年龄、性别、肌酐、血红蛋白、白细胞以及晚期纤维化显著相关（均P<0.05）。多因素逻辑回归分析显示，RPR是预测NAFLD患者晚期纤维化（纤维化-4计算器≥1.3）的独立因素（OR：5.718，95%CI：3.326-9.830，P<0.001）。
结论
我们的研究结果表明，RPR与非酒精性脂肪性肝病患者的晚期纤维化显著相关。
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