D'Alessandris Nicoletta, Lucatelli Pierleone, Tripodi Domenico, Amabile Maria Ida, Ascoli Valeria
Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.
Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Diagn Cytopathol. 2019 Nov;47(11):1213-1217. doi: 10.1002/dc.24287. Epub 2019 Jul 26.
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a very rare CD30-positive ALK-negative T-cell non-Hodgkin lymphoma included as a provisional entity in the 2017 WHO classification of lymphoid neoplasms. BIA-ALCL arises as proliferating cells over the surface of the implant. It is generally an indolent disease if confined within the fibrous capsule. In contrast, mass and/or infiltration beyond the capsule is much more aggressive. This report describes a case of infiltrative BIA-ALCL with massive pleural effusion containing hallmark BIA-ALCL cells showing the characteristic morphologic appearance of high-grade anaplastic lymphoma, CD30-positive but ALK-negative with variable staining for T-cell antigens. Detailed cytological features of BIA-ALCL in pleural fluid are described along with the results of a literature search performed for BIA-ALCL cases with pleural effusion. This report expands the spectrum of BIA-ALCL pathology to include chest wall involvement and pleural effusion.
乳房植入物相关间变性大细胞淋巴瘤（BIA-ALCL）是一种非常罕见的CD30阳性、ALK阴性T细胞非霍奇金淋巴瘤，在2017年世界卫生组织淋巴肿瘤分类中被列为临时实体。BIA-ALCL表现为植入物表面的增殖细胞。如果局限于纤维囊内，它通常是一种惰性疾病。相比之下，超出囊外的肿块和/或浸润则更具侵袭性。本报告描述了一例浸润性BIA-ALCL病例，伴有大量胸腔积液，积液中含有典型的BIA-ALCL细胞，呈现高级别间变性淋巴瘤的特征性形态，CD30阳性但ALK阴性，T细胞抗原染色可变。本文描述了胸腔积液中BIA-ALCL的详细细胞学特征，并对伴有胸腔积液的BIA-ALCL病例进行了文献检索。本报告扩展了BIA-ALCL病理学的范围，将胸壁受累和胸腔积液纳入其中。
