Aicardi J, Gastaut H, Misès J
National Institute for Health and Medical Investigation, Hospital of Sick Children, Paris, France.
Arch Neurol. 1988 Aug;45(8):923-5. doi: 10.1001/archneur.1988.00520320125029.
A girl of borderline intelligence developed repeated syncopal attacks that were compulsively self-induced, apparently by forced expiration against a closed glottis (Valsalva's maneuver). In addition, she had typical absence seizures triggered by her apneic attacks, which could also be induced by hyperventilation. The absence seizures were suppressed by treatment with valproate sodium, which had no effect on the self-induced apneas. These were considerably improved with fenfluramine hydrochloride treatment, which was also associated with marked improvement of her previously abnormal behavior.
一名智力处于临界水平的女孩反复出现晕厥发作，这些发作是她强迫自己诱发的，显然是通过紧闭声门用力呼气（瓦尔萨尔瓦动作）。此外，她有典型的失神发作，由呼吸暂停发作引发，过度换气也可诱发。丙戊酸钠治疗可抑制失神发作，但对她自行诱发的呼吸暂停无效。盐酸芬氟拉明治疗使呼吸暂停情况有了显著改善，同时她之前的异常行为也有了明显改善。
