染色体倒位预测了具有不同行为表型的物种中性类固醇相关基因的表达。
A chromosomal inversion predicts the expression of sex steroid-related genes in a species with alternative behavioral phenotypes.
机构信息
Department of Psychology, Emory University, Atlanta, GA, 30322, USA; Departments of Anthropology and Biology, Pennsylvania State University, University Park, PA, 16802, USA.
Department of Psychology, Emory University, Atlanta, GA, 30322, USA.
出版信息
Mol Cell Endocrinol. 2019 Sep 15;495:110517. doi: 10.1016/j.mce.2019.110517. Epub 2019 Jul 23.
In white-throated sparrows, a chromosomal rearrangement has led to alternative phenotypes that differ in sex steroid-dependent behaviors. The rearrangement has captured the genes estrogen receptor alpha and 5-alpha reductase, making these genes strong candidates for mediating the behavioral phenotypes. We report here that of the two genes, expression of estrogen receptor alpha mRNA differs between the morphs and predicts behavior to a much greater extent than does expression of 5-alpha reductase mRNA. Differentiation of estrogen receptor alpha, therefore, is likely more important for the behavioral phenotypes. We also found that in some brain regions, the degree to which testosterone treatment affects the expression of steroid-related genes depends strongly on morph. A large morph difference in estrogen receptor alpha mRNA expression in the amygdala appears to be independent of plasma testosterone; this difference persists during the non-breeding season and is detectable in nestlings at post-hatch day seven. The latter result suggests a substrate for organizational effects of hormones during development.
在白喉雀中，一种染色体重排导致了依赖于性激素的行为表现不同的表型。该重排捕获了雌激素受体 alpha 和 5-alpha 还原酶基因，使这些基因成为介导行为表型的重要候选基因。我们在这里报告，在这两个基因中，雌激素受体 alpha mRNA 的表达在两种形态之间存在差异，并且比 5-alpha 还原酶 mRNA 的表达更能预测行为，因此，雌激素受体 alpha 的分化可能对行为表型更为重要。我们还发现，在某些脑区，睾酮处理对类固醇相关基因表达的影响在很大程度上取决于形态。在杏仁核中，雌激素受体 alpha mRNA 表达的巨大形态差异似乎与血浆睾酮无关；这种差异在非繁殖季节持续存在，并可在孵化后第 7 天的雏鸟中检测到。后一个结果表明了激素在发育过程中具有组织效应的基础。
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