Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Brian Tumor, Beijing, China.
Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
World Neurosurg. 2019 Nov;131:e265-e270. doi: 10.1016/j.wneu.2019.07.128. Epub 2019 Jul 23.
To investigate the expression characteristics and prognostic value of transforming growth factor β1 (TGF-β1) in primary skull base chordomas (SBCs).
The mRNA expression levels of TGF-β1 were measured in 57 frozen samples from patients with primary SBCs. Clinical data collection, follow-up, correlations, and survival analyses were performed.
In the series of 57 patients (29 men and 28 women) with primary SBCs, the mean value of TGF-β1 mRNA was 1.713 with a median of 0.904. Twenty-four SBCs were soft type and 33 were hard type. The Mann-Whitney U test revealed that the expression level of TGF-β1 mRNA in hard type SBCs was significantly higher than the expression level found in the soft type (P = 0.03). The independent-samples median test suggested that the expression level of TGF-β1 mRNA in female patients' SBCs was significantly higher than that in male patients' SBCs (P = 0.01). Expression differences of TGF-β1 were not seen among different pathological subtypes, tumor blood supply, or degree of resection. The Spearman rank correlation coefficient clarified that TGF-β1 mRNA levels were not correlated with tumor diameter, preoperative Karnofsky Performance Status (KPS), postoperative KPS, follow-up KPS, age, or intraoperative blood loss. The multivariate Cox analysis revealed that pathological subtype (P = 0.008), expression level of TGF-β1 mRNA (P = 0.01), and tumor texture (P = 0.03) were all independent prognostic factors for tumor progression.
SBCs in female patients and SBCs with hard texture were prone to have high TGF-β1 mRNA expression. High expression of TGF-β1, hard tumor texture, and conventional subtype were all independent risk factors for tumor progression.
研究转化生长因子β1（TGF-β1）在原发性颅底脊索瘤（SBC）中的表达特征及其预后价值。
对 57 例原发性 SBC 患者的 57 例冷冻标本进行 TGF-β1mRNA 表达水平的检测。进行临床资料收集、随访、相关性和生存分析。
在 57 例（29 名男性和 28 名女性）原发性 SBC 患者中，TGF-β1mRNA 的平均值为 1.713，中位数为 0.904。24 例 SBC 为软型，33 例为硬型。Mann-Whitney U 检验显示，硬型 SBC 中 TGF-β1mRNA 的表达水平明显高于软型（P=0.03）。独立样本中位数检验表明，女性患者 SBC 中 TGF-β1mRNA 的表达水平明显高于男性患者（P=0.01）。TGF-β1 的表达差异与不同的病理亚型、肿瘤血供或切除程度无关。Spearman 秩相关系数表明，TGF-β1mRNA 水平与肿瘤直径、术前卡诺夫斯基表现状态（KPS）、术后 KPS、随访 KPS、年龄或术中失血量均无相关性。多变量 Cox 分析表明，病理亚型（P=0.008）、TGF-β1mRNA 表达水平（P=0.01）和肿瘤质地（P=0.03）均为肿瘤进展的独立预后因素。
女性患者的 SBC 和质地坚硬的 SBC 更易出现 TGF-β1mRNA 高表达。TGF-β1 高表达、肿瘤质地坚硬和常规亚型均为肿瘤进展的独立危险因素。
