对扎伊尔农村地区艾滋病的世界卫生组织临床病例定义的评估。
Evaluation of the WHO clinical case definition for AIDS in rural Zaire.
作者信息
De Cock K M, Colebunders R, Francis H, Nzilambi N, Laga M, Ryder R W, Bondjobo M, McCormick J B, Piot P
机构信息
Division of Viral Diseases, Center for Infectious Diseases, Atlanta, GA 30333.
出版信息
AIDS. 1988 Jun;2(3):219-21.
The clinical case definition for AIDS proposed by WHO for use in Africa was evaluated against HIV antibody status in 72 patients in rural Zaire. Twenty-one (29%) of the patients were antibody-positive. For diagnosing anti-HIV seropositivity, the case definition had a sensitivity of 52%, a specificity of 78%, a positive predictive value of 50% and a negative predictive value of 80%. Calculation of the positive predictive value at different levels of prevalence of HIV infection suggests that the case definition operates at maximum reliability in selected high-risk groups. Modifications to the case definition should be evaluated to try and improve its sensitivity and positive predictive value.
世界卫生组织提议用于非洲的艾滋病临床病例定义，在扎伊尔农村地区的72名患者中，对照HIV抗体状况进行了评估。其中21名（29%）患者抗体呈阳性。对于诊断抗HIV血清阳性，该病例定义的敏感度为52%，特异度为78%，阳性预测值为50%，阴性预测值为80%。对不同HIV感染流行水平下的阳性预测值计算表明，该病例定义在选定的高危人群中以最大可靠性发挥作用。应对病例定义进行修改评估，以尝试提高其敏感度和阳性预测值。
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