营养与大脑发育：优化早期神经发育之路：系统评价。
Nutrition and the developing brain: the road to optimizing early neurodevelopment: a systematic review.
机构信息
Department of Neonatology, 18th Medical Operations Squadron, Kadena AB, Okinawa, Japan.
Division of Neonatology, Children's National Health System, 111 Michigan Avenue NW, Washington, DC, 20010, USA.
出版信息
Pediatr Res. 2020 Jan;87(2):194-201. doi: 10.1038/s41390-019-0508-3. Epub 2019 Jul 26.
Abstract
BACKGROUND
Neonatal intensive care practices have resulted in marked improvements in the survival of premature infants; however, they remain at significant risk for adverse neurodevelopmental outcomes. The impact of current nutritional practices on brain development following early extra-uterine exposure in premature infants is not well known.
METHODS
We performed a systematic review to investigate nutritional effects on postnatal brain development in healthy term and prematurely born infants utilizing advanced magnetic resonance imaging tools.
RESULTS
Systematic screen yielded 595 studies for appraisal. Of these, 22 total studies were selected for inclusion in the review, with findings summarized in a qualitative, descriptive fashion.
CONCLUSION
Fat and energy intake are associated with improved brain volume and development in premature infants. While breast milk intake and long-chain polyunsaturated fatty acid supplementation has been proven beneficial in term infants, the impact in preterm infants is less well understood.
摘要
背景
新生儿重症监护实践显著提高了早产儿的存活率；然而，他们仍然面临着不良神经发育结果的重大风险。目前的营养实践对早产儿早期宫外暴露后大脑发育的影响尚不清楚。
方法
我们进行了一项系统评价，利用先进的磁共振成像工具研究营养对健康足月和早产儿出生后大脑发育的影响。
结果
系统筛选得到 595 项研究进行评估。其中，有 22 项总研究被选入综述，以定性、描述性的方式总结研究结果。
结论
脂肪和能量摄入与早产儿脑容量和发育的改善有关。虽然母乳喂养和长链多不饱和脂肪酸补充已被证明对足月婴儿有益，但对早产儿的影响了解较少。
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2
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