怀孕期间的社会支持是否会影响母体 DNA 甲基化？一项非裔美国人队列研究的结果。
Can social support during pregnancy affect maternal DNA methylation? Findings from a cohort of African-Americans.
机构信息
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
出版信息
Pediatr Res. 2020 Jul;88(1):131-138. doi: 10.1038/s41390-019-0512-7. Epub 2019 Jul 26.
BACKGROUND
While stress and the absence of social support during pregnancy have been linked to poor health outcomes, the underlying biological mechanisms are unclear.
METHODS
We examined whether adverse experiences during pregnancy alter DNA methylation (DNAm) in maternal epigenomes. Analyses included 250 African-American mothers from the Boston Birth Cohort. Genome-wide DNAm profiling was performed in maternal blood collected after delivery, using the Infinium HumanMethylation450 Beadchip. Linear regression models, with adjustment of pertinent covariates, were applied.
RESULTS
While self-reported maternal psychosocial lifetime stress and stress during pregnancy was not associated with DNAm alterations, we found that absence of support from the baby's father was significantly associated with maternal DNAm changes in TOR3A, IQCB1, C7orf36, and MYH7B and that lack of support from family and friends was associated with maternal DNA hypermethylation on multiple genes, including PRDM16 and BANKL.
CONCLUSIONS
This study provides intriguing results suggesting biological embedding of social support during pregnancy on maternal DNAm, warranting additional investigation, and replication.
背景
虽然孕期压力和缺乏社会支持与不良健康结果有关，但潜在的生物学机制尚不清楚。
方法
我们研究了孕期不良经历是否会改变母体表观基因组中的 DNA 甲基化（DNAm）。分析包括来自波士顿出生队列的 250 名非裔美国母亲。使用 Infinium HumanMethylation450 Beadchip 在产后采集的母体血液中进行全基因组 DNAm 分析。应用线性回归模型，并调整相关协变量。
结果
虽然自我报告的母亲终生心理社会压力和孕期压力与 DNAm 改变无关，但我们发现，婴儿父亲的支持缺失与 TOR3A、IQCB1、C7orf36 和 MYH7B 上的母体 DNAm 变化显著相关，而缺乏来自家人和朋友的支持与包括 PRDM16 和 BANKL 在内的多个基因上的母体 DNA 高甲基化相关。
结论
这项研究提供了有趣的结果，表明孕期社会支持的生物学嵌入对母体 DNAm 有影响，值得进一步研究和复制。
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