Istanbul Technical University, Department of Physics Engineering, Maslak, 34469 Istanbul, Turkey.
FPInnovations, 2665 East Mall, Vancouver, BC V6T 1Z4, Canada.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109838. doi: 10.1016/j.msec.2019.109838. Epub 2019 May 30.
The objective of the study was to obtain multifunctional core shell nanostructures of superparamagnetic iron oxide nanoparticles (FeO) coated with various ionic biopolymers that can optimize toxicity to healthy cells, colloidal instabilities and drug loading capacities. These nanostructures can also allow drug delivery to tumor tissue because of their magnetic properties, accumulation and drug release at tumor site could be controlled by means of an external magnetic field. The impact of the biopolymers with different ionic properties to final core shell structures were investigated and compared in terms of their colloidal properties, cytotoxicities, drug adsorption and drug delivery capacities. Besides, the effect of the surface charges on the healthy cells and cancer cells is very important factor affecting toxicity and drug delivery. The results showed that the drug delivery agents coated with cationic biopolymers with cationic surface properties significantly reduced cancer cell viability compared to the anionic and nonionic polymer coatings even though their drug loading capacities were found to be the lowest.
本研究的目的是获得具有超顺磁性氧化铁纳米粒子（FeO）的多功能核壳纳米结构，该结构涂覆有各种离子型生物聚合物，可优化对健康细胞的毒性、胶体不稳定性和药物载药量。由于这些纳米结构具有磁性，因此可以将药物递送到肿瘤组织，通过外部磁场可以控制药物在肿瘤部位的积累和释放。研究了具有不同离子特性的生物聚合物对最终核壳结构的影响，并从胶体性质、细胞毒性、药物吸附和药物输送能力等方面进行了比较。此外，表面电荷对健康细胞和癌细胞的影响是影响毒性和药物输送的一个非常重要的因素。结果表明，与阴离子和非离子聚合物涂层相比，涂覆有带正电荷的生物聚合物的药物输送剂具有带正电荷的表面特性，即使它们的药物载药量最低，也能显著降低癌细胞的活力。
