Dall'Olio F, Malagolini N, Serafini-Cessi F
Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.
Biosci Rep. 1987 Dec;7(12):925-32. doi: 10.1007/BF01122125.
Guinea-pig kidney contains a beta-4-N-acetylgalactosaminyltransferase which may be involved in the biosynthesis of the Sda determinant expressed on Tamm-Horsfall glycoprotein. In the present study we show that this enzyme is expressed far more in the medulla than in the cortex of the kidney and that, among the other organs tested, is expressed only in colon and caecum. This transferase is ontogenically regulated, in that its activity is low at birth and increases as a function of age. From several aspects, the tissue distribution and the ontogenic expression of beta-4-N-acetylgalactosaminyltransferase and Tamm-Horsfall glycoprotein are similar.
豚鼠肾脏含有一种β-4-N-乙酰半乳糖胺基转移酶，该酶可能参与了表达于Tamm-Horsfall糖蛋白上的Sda决定簇的生物合成。在本研究中，我们发现这种酶在肾脏髓质中的表达远高于皮质，并且在其他所检测的器官中，仅在结肠和盲肠中有表达。这种转移酶受到个体发育的调控，其活性在出生时较低，并随年龄增长而增加。从多个方面来看，β-4-N-乙酰半乳糖胺基转移酶和Tamm-Horsfall糖蛋白的组织分布及个体发育表达情况相似。
