血管加压素、去氨基-（D-精氨酸8）-血管加压素和肾上腺素对绵羊的抗血友病作用：关于一种体内检测系统的提议

Antihaemophilic effect of vasopressin, deamino-(D-arginine8)-vasopressin and adrenaline in sheep: proposal for an in vivo assay system.

作者信息

Heiniger J, Kissling-Albrecht L, Neuenschwander S, Rösli R, Pliska V

机构信息

Institute of Animal Science, Swiss Federal Institute of Technology, ETH Zürich, Switzerland.

出版信息

Br J Pharmacol. 1988 Jun;94(2):279-81. doi: 10.1111/j.1476-5381.1988.tb11525.x.

DOI:10.1111/j.1476-5381.1988.tb11525.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853979/

Abstract

Female sheep were used to assay antihaemophilic (factor VIII enhancing) activity of arginine vasopressin, deamino-(D-arginine8)-vasopressin (DDAVP) and adrenaline. The time course of the response was biphasic, two surges of factor VIII being observed. DDAVP was found to be the most potent of the substances investigated. Its optimal dose was 1 microgram kg-1 body wt (i.v.). It is suggested that a similar procedure can be employed to search for new peptides with anti-haemophilic action.

摘要

使用雌性绵羊来测定精氨酸加压素、去氨基-（D-精氨酸8）-加压素（DDAVP）和肾上腺素的抗血友病（因子VIII增强）活性。反应的时间过程是双相的，观察到因子VIII有两个峰值。发现DDAVP是所研究物质中最有效的。其最佳剂量为1微克/千克体重（静脉注射）。建议可以采用类似的方法来寻找具有抗血友病作用的新肽。

相似文献

1

Antihaemophilic effect of vasopressin, deamino-(D-arginine8)-vasopressin and adrenaline in sheep: proposal for an in vivo assay system.血管加压素、去氨基-（D-精氨酸8）-血管加压素和肾上腺素对绵羊的抗血友病作用：关于一种体内检测系统的提议

Br J Pharmacol. 1988 Jun;94(2):279-81. doi: 10.1111/j.1476-5381.1988.tb11525.x.

2

Effects of neurohypophyseal hormone analogues on blood clotting factor VIII and fibrinolytic activity in sheep.神经垂体激素类似物对绵羊血液凝血因子VIII和纤溶活性的影响。

Eur J Pharmacol. 1997 Apr 4;323(2-3):205-13. doi: 10.1016/s0014-2999(97)00036-8.

3

1-Deamino-8-D-arginine vasopressin in the treatment of non-haemophilic patients with acquired factor VIII inhibitor.1-去氨基-8-D-精氨酸加压素治疗获得性因子VIII抑制剂的非血友病患者

Haemostasis. 1990;20(1):15-20. doi: 10.1159/000216100.

4

Plasma concentrations of factor VIII after administration of DDAVP to conscious dogs.

Thromb Res. 1987 Sep 1;47(5):585-91. doi: 10.1016/0049-3848(87)90363-x.

5

Factor VIII-related activities after 1-deamino-8-D-arginine vasopressin in multicentric reticulohistiocytosis.

Ric Clin Lab. 1984 Jan-Mar;14(1):37-9. doi: 10.1007/BF02905038.

6

[Studies on the properties of the factor VIII after DDAVP (1-deamino-8-D-arginine vasopressin) in normal individuals (author's transl)].正常人应用去氨加压素（1-去氨基-8-D-精氨酸血管加压素）后因子VIII特性的研究（作者译）

Nihon Ketsueki Gakkai Zasshi. 1980 Oct;43(5):907-17.

7

Vasopressin and 1-deamino-8-D-arginine-vasopressin (DDAVP) reduce elevated plasma catecholamine levels in rats with hypothalamic deafferentation.血管加压素和1-去氨基-8-D-精氨酸血管加压素（DDAVP）可降低下丘脑传入神经切断大鼠升高的血浆儿茶酚胺水平。

Cell Mol Neurobiol. 1988 Jun;8(2):225-33. doi: 10.1007/BF00711248.

8

Absent factor VIII response to synthetic vasopressin analogue (DDAVP) in nephrogenic diabetes insipidus.

Lancet. 1985 Jun 8;1(8441):1293-4. doi: 10.1016/s0140-6736(85)92790-4.

9

DDAVP: does the drug have a direct effect on the vessel wall?去氨加压素：该药物对血管壁有直接作用吗？

Thromb Res. 1983 Jul 15;31(2):239-53. doi: 10.1016/0049-3848(83)90326-2.

10

[Effect of 1-deamino-8-D-arginine vasopressin (DDAVP) on bleeding time in uremic patients].

Rev Med Chil. 1985 Aug;113(8):763-8.

本文引用的文献

1

Increase in antihaemophilic globulin activity following infusion of adrenaline.输注肾上腺素后抗血友病球蛋白活性增加。

J Physiol. 1961 Apr;156(2):217-24. doi: 10.1113/jphysiol.1961.sp006670.

2

The effect of desamino-D-arginine vasopressin (DDAVP) and naloxone infusions on factor VIII and possible endothelial cell (EC) related activities.去氨基-D-精氨酸血管加压素（DDAVP）和纳洛酮输注对凝血因子VIII及可能的内皮细胞相关活性的影响。

Br J Haematol. 1984 Aug;57(4):651-62.

3

Hormonal and cardiovascular responses to DDAVP in man.

Clin Endocrinol (Oxf). 1986 Jan;24(1):89-96. doi: 10.1111/j.1365-2265.1986.tb03258.x.

4

Plasma concentrations of factor VIII after administration of DDAVP to conscious dogs.

Thromb Res. 1987 Sep 1;47(5):585-91. doi: 10.1016/0049-3848(87)90363-x.

5

Mechanism of plasminogen activator and factor VIII increase after vasoactive drugs.血管活性药物作用后纤溶酶原激活物及凝血因子 VIII 增加的机制

Br J Haematol. 1975 May;30(1):81-93. doi: 10.1111/j.1365-2141.1975.tb00521.x.

6

Specificity in the factor VIII response to vasopressin infusion in man.

Br J Haematol. 1979 Mar;41(3):437-47. doi: 10.1111/j.1365-2141.1979.tb05878.x.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。