抗病毒信号与糖酵解之间的拮抗作用。
Antagonism between Antiviral Signaling and Glycolysis.
机构信息
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B17 2TT, UK.
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
出版信息
Trends Endocrinol Metab. 2019 Sep;30(9):571-573. doi: 10.1016/j.tem.2019.07.010. Epub 2019 Jul 23.
Abstract
RIG-I-like receptor (RLR)-mediated interferon production is critical for antiviral responses. A recent study (Zhang et al., Cell, 2019) uncovered a reciprocal inhibition between RLR signaling and glycolysis: lactate produced by glycolysis inhibits RLR signaling by binding to RLR signaling component mitochondrial antiviral-signaling (MAVS), whereas RLR activation suppresses glycolysis through inhibiting glycolysis enzyme hexokinase.
摘要
RLR 介导的干扰素产生对于抗病毒反应至关重要。最近的一项研究（Zhang 等人，《细胞》，2019 年）揭示了 RLR 信号与糖酵解之间的相互抑制作用：糖酵解产生的乳酸通过与 RLR 信号成分线粒体抗病毒信号（MAVS）结合来抑制 RLR 信号，而 RLR 激活则通过抑制糖酵解酶己糖激酶来抑制糖酵解。
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