Harmon Elizabeth, Lebin Jacob, Murphy David, Watsjold Bjorn
Emergency Medicine, University of Washington, Seattle, Washington, USA.
BMJ Case Rep. 2019 Jul 26;12(7):e229947. doi: 10.1136/bcr-2019-229947.
While potassium cyanide poisoning has been well described, the toxicity of potassium gold cyanide is less well understood. This case describes an 84-year-old man who presented after an intentional ingestion of 0.5-1 teaspoons of potassium gold cyanide. Despite antidotal therapy, the patient rapidly developed severe lactic acidosis, multiorgan dysfunction and ultimately expired. While the patient's clinical findings were consistent with acute cyanide poisoning, a serum cyanide level was below the toxic threshold. Previous reports have suggested that gold toxicity may also contribute to the effects of potassium gold cyanide, and may have played a role in the patient's rapid decline. In addition to treatment of cyanide toxicity, management of acute gold toxicity should also be considered in potassium gold cyanide ingestion.
虽然氰化钾中毒已有详尽描述,但氰化亚金钾的毒性却鲜为人知。本病例介绍了一名84岁男性,他故意摄入了0.5至1茶匙氰化亚金钾后前来就诊。尽管进行了解毒治疗,但患者迅速出现严重乳酸酸中毒、多器官功能障碍,最终死亡。虽然患者的临床表现与急性氰化物中毒相符,但血清氰化物水平低于中毒阈值。先前的报告表明,金中毒也可能导致氰化亚金钾的毒性作用,并且可能在患者的迅速病情恶化中起了作用。除了治疗氰化物中毒外,对于氰化亚金钾摄入,还应考虑对急性金中毒的处理。