Coentrão Luûs, Neves Aida, Moura Daniel
Institute of Pharmacology and Therapeutics, University of Porto and Hospital de S. João EPE, Porto, Portugal.
BMJ Case Rep. 2010 Jul 15;2010:bcr0120102603. doi: 10.1136/bcr.01.2010.2603.
Acute cyanide poisoning by ingestion is often severe and lethal among jewellery industry workers. Clinical experience with hydroxocobalamin alone in severe acute cyanide poisoning by ingestion remains limited. This case concerns a 50-year-old goldsmith who tried suicide by ingestion of a jewellery cleaner solution containing approximately 1.2 g of potassium cyanide. He presented unconsciousness, with severe lactic acidosis and arteriolisation of venous blood gases. Following hydroxocobalamin treatment, neurologic and metabolic disorders rapidly improved. He was discharged home 4 days later, without neurological sequelae. The case reinforces the safety and effectiveness of hydroxocobalamin in acute cyanide poisoning by ingestion.
对于珠宝行业工人来说，经口摄入导致的急性氰化物中毒往往很严重且会致命。单独使用羟钴胺治疗严重经口急性氰化物中毒的临床经验仍然有限。本病例涉及一名50岁的金匠，他试图通过摄入一种含有约1.2克氰化钾的珠宝清洁液自杀。他出现昏迷，伴有严重的乳酸酸中毒和静脉血气的动脉化。经过羟钴胺治疗后，神经和代谢紊乱迅速改善。4天后他出院回家，没有神经后遗症。该病例强化了羟钴胺在经口急性氰化物中毒治疗中的安全性和有效性。
