在中国人群中，与贝赫切特病相关的是 MICA*049，而不是 MICA*009。
MICA*049, not MICA*009, is associated with Behçet's disease in a Chinese population.
机构信息
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Nanchang University, Nanchang, China.
Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, USA.
出版信息
Sci Rep. 2019 Jul 26;9(1):10856. doi: 10.1038/s41598-019-47289-z.
Behçet's disease (BD) is a multi-systemic inflammatory disease. Previous reports indicated that MICA009 confers susceptibility to BD. MICA049 differs from MICA009:01, a major MICA009 subtype, only at codon 335 in exon 6. However, the potential association of MICA049 with BD has not been addressed. In this study, we differentiated association among MICA049, MICA009 and HLA-B51 with BD. A Han Chinese cohort consisting of 41 BD patients and 197 ethnically matched controls were examined with sequencing and T-ARMS-PCR for genotyping of MICA, and ARMS-PCR for HLA-B51. The phenotype frequency of MICA049 (41.5% versus 8.1%, OR = 8.01, P = 1.91 × 10) and HLA-B51 (46.3% versus 15.7%, OR = 4.62, P = 1.21 × 10) were significantly higher in BD patients than those in controls, whereas MICA009 showed no significant difference between the two groups (17.1% versus 13.2%, OR = 1.35, P = 0.51). After stratification for the effect of HLA-B51, MICA049 was still associated with BD in HLA-B51 negative patients (OR = 40.61, P = 0.02). Our results indicate that MICA049, not MICA009, is a risk factor to BD, and that is independent from HLA-B51 in the Han Chinese cohort.
贝切特病（BD）是一种多系统炎症性疾病。先前的报告表明，MICA009 赋予了 BD 的易感性。MICA049 与 MICA009 不同，仅在第 6 外显子的 335 位密码子上有所不同，MICA009 是 MICA009 的主要亚型。然而，MICA049 与 BD 的潜在关联尚未得到解决。在这项研究中，我们区分了 MICA049、MICA009 和 HLA-B51 与 BD 的关联。一个由 41 名 BD 患者和 197 名种族匹配的对照组成的汉族队列接受了测序和 T-ARMS-PCR 用于 MICA 基因分型，以及 ARMS-PCR 用于 HLA-B51 检测。BD 患者的 MICA049 表型频率（41.5%比 8.1%，OR=8.01，P=1.91×10）和 HLA-B51 表型频率（46.3%比 15.7%，OR=4.62，P=1.21×10）明显高于对照组，而 MICA009 在两组之间没有显著差异（17.1%比 13.2%，OR=1.35，P=0.51）。在分层分析 HLA-B51 的影响后，MICA049 在 HLA-B51 阴性患者中仍与 BD 相关（OR=40.61，P=0.02）。我们的结果表明，MICA049 而不是 MICA009 是 BD 的危险因素，并且在汉族人群中与 HLA-B*51 无关。
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