Bischoff-Ferrari Heike A
Departement für Geriatrie und Altersforschung, Universitätsspital Zürich.
Dtsch Med Wochenschr. 2019 Aug;144(15):1018-1021. doi: 10.1055/a-0851-9737. Epub 2019 Jul 26.
Four meta-analyzes on the effect of vitamin D on fracture prevention were published between 2016 and 2018. Two of these meta-analyzes focused on the primary prevention of fractures in adults aged 50 and over who were not at risk for fractures or vitamin D deficiency. Another meta-analysis focused on the combination of vitamin D plus calcium and the most recently published meta-analysis focused on the individual effect of vitamin D without calcium. In terms of current guidelines, it is important to note that only 1 out of the 3 most recent meta-analyzes were predominantly directed at adults over the age of 65 with an increased risk of falls, fractures, and vitamin D deficiency.What can we recommend now? Based on our critical review of the meta-analyzes on vitamin D and fracture prevention, vitamin D supplementation with or without calcium is still useful in older adults, ages 65 and older, with an increased risk of vitamin D deficiency and an increased risk of fracture.
2016年至2018年间发表了四项关于维生素D对预防骨折效果的荟萃分析。其中两项荟萃分析聚焦于50岁及以上无骨折风险或维生素D缺乏风险的成年人骨折的一级预防。另一项荟萃分析关注维生素D加钙的联合使用，而最近发表的荟萃分析则聚焦于不含钙的维生素D的个体效应。就当前指南而言，需要注意的是，最近三项荟萃分析中只有一项主要针对65岁以上、跌倒、骨折和维生素D缺乏风险增加的成年人。我们现在能给出什么建议呢？基于我们对维生素D与骨折预防的荟萃分析的批判性综述，无论是否补充钙，补充维生素D对65岁及以上、维生素D缺乏风险增加且骨折风险增加的老年人仍然有用。
