School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan.
Department of Information Management, National Taipei University of Nursing and Health Sciences, 365 Ming-Te Road, Peitou District, Taipei, 112, Taiwan.
Nutr J. 2019 Jul 27;18(1):42. doi: 10.1186/s12937-019-0467-x.
Chronic Kidney Disease (CKD), characterized by an impaired kidney function, is associated with low testosterone levels. This study investigated the association between dietary patterns, testosterone levels, and severity of impaired kidney function among middle-aged and elderly men.
This cross-sectional study used the database from a private health-screening institute in Taiwan between 2008 and 2010. Men aged 40 years old and older (n = 21,376) with estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m and proteinuria were selected. Among 21,376 men, 256 men had available measurements of testosterone levels. Dietary assessment was conducted using a food frequency questionnaire and three dietary patterns (fried-processed, vege-seafood, and dairy-grain dietary patterns) were identified using principal component analysis.
Men in the lower tertiles (T1 and T2) of eGFR had significantly decreased testosterone levels by 0.8 (95% CI: - 1.40, - 0.20) and 0.9 nmol/L (95% CI: - 1.43, - 0.33). Furthermore, serum triglycerides (TG) levels were inversely associated with testosterone levels (β = - 0.51, 95% CI: - 0.77, - 0.24). Men in the higher tertile of fried-processed dietary pattern scores were associated with decreased testosterone levels by 0.8 nmol/L (95% CI: - 1.40, - 0.16), reduced testosterone-to-TG (T/TG) ratio by 1.8 units (95% CI: - 2.99, - 0.53), and increased risk of moderate/severe impaired kidney function (eGFR < 60 mL/min/1.73 m) and proteinuria severity by 1.35 (95% CI: 1.15, 1.58) and 1.18 (95% CI: 1.02, 1.37) times respectively. In contrast, the vege-seafood dietary pattern was negatively associated with severity of impaired kidney function and proteinuria after multivariable adjustment, but had no association with testosterone levels and T/TG ratio.
The fried-processed dietary pattern is negatively associated with testosterone levels but positively associated with the severity of impaired kidney function. However, the vege-seafood and dairy-grain dietary patterns appear to have beneficial effects.
慢性肾脏病（CKD）的特征是肾功能受损，与低睾酮水平有关。本研究调查了中年和老年男性的饮食模式、睾酮水平与肾功能受损严重程度之间的关系。
本横断面研究使用了台湾一家私人健康筛查机构 2008 年至 2010 年的数据库。选择肾小球滤过率（eGFR）<90 mL/min/1.73 m 和蛋白尿的年龄在 40 岁及以上的男性（n=21376）。在 21376 名男性中，有 256 名男性的睾酮水平可测量。饮食评估采用食物频率问卷进行，采用主成分分析确定三种饮食模式（油炸加工、蔬菜海鲜和奶制品谷物饮食模式）。
eGFR 较低的三分位（T1 和 T2）男性的睾酮水平分别降低了 0.8（95%CI：-1.40，-0.20）和 0.9 nmol/L（95%CI：-1.43，-0.33）。此外，血清甘油三酯（TG）水平与睾酮水平呈负相关（β=-0.51，95%CI：-0.77，-0.24）。摄入较高水平油炸加工饮食模式评分的男性，其睾酮水平降低 0.8 nmol/L（95%CI：-1.40，-0.16），睾酮与 TG（T/TG）比值降低 1.8 个单位（95%CI：-2.99，-0.53），中度/重度肾功能受损（eGFR <60 mL/min/1.73 m）和蛋白尿严重程度的风险分别增加 1.35 倍（95%CI：1.15，1.58）和 1.18 倍（95%CI：1.02，1.37）。相比之下，蔬菜海鲜饮食模式与肾功能受损严重程度和蛋白尿严重程度在进行多变量调整后呈负相关，但与睾酮水平和 T/TG 比值无相关性。
油炸加工饮食模式与睾酮水平呈负相关，但与肾功能受损严重程度呈正相关。然而，蔬菜海鲜和奶制品谷物饮食模式似乎有有益的影响。
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