School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan.
Department of Information Management, National Taipei University of Nursing and Health Sciences, 365 Ming-Te Road, Peitou District, Taipei 11219, Taiwan.
Nutrients. 2019 Sep 2;11(9):2052. doi: 10.3390/nu11092052.
Dyslipidemia, anemia, and inflammation are associated with declined kidney function. This study investigated the association of inflammatory dietary pattern with dyslipidemia, anemia, and kidney function biomarkers among middle-aged and older Taiwanese adults with declined kidney function. Biochemical data and food frequency questionnaire were obtained from 41,128 participants with estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m and positive urinary protein. Inflammatory dietary pattern was identified by reduced rank regression with C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (N/L) as response variables. Males had higher prevalence of dyslipidemia and higher inflammatory markers, but lower prevalence of anemia and lower eGFR levels compared to females. Inflammatory dietary pattern characterized with low intakes of seafood, grains, vegetables, and fruits but high intakes of meat, eggs, preserved/processed foods, and sugary drinks was associated with an increased risk of dyslipidemia by 21% in males and an increased risk of anemia by 28-47% in both genders. Furthermore, high consumption of inflammatory dietary pattern was associated with reduced eGFR (males β = -0.85, 95% CI -1.26 to -0.43, females β = -0.53, 95% CI -0.98 to -0.08) and increased N/L and/or CRP in both genders. In conclusion, inflammatory dietary pattern is positively associated with dyslipidemia, anemia, and decreased kidney function in middle-aged and older adults with declined kidney function.
血脂异常、贫血和炎症与肾功能下降有关。本研究调查了炎症性饮食模式与中年和老年肾功能下降的台湾成年人血脂异常、贫血和肾功能生物标志物之间的关系。从估计肾小球滤过率（eGFR）<90 mL/min/1.73 m 和尿蛋白阳性的 41128 名参与者中获得生化数据和食物频率问卷。炎症性饮食模式通过 C 反应蛋白（CRP）和中性粒细胞与淋巴细胞比值（N/L）作为反应变量进行降秩回归确定。与女性相比，男性血脂异常和炎症标志物的患病率较高，但贫血和 eGFR 水平较低。以海鲜、谷物、蔬菜和水果摄入量低，而肉类、鸡蛋、腌制/加工食品和含糖饮料摄入量高为特征的炎症性饮食模式与男性血脂异常风险增加 21%以及两性贫血风险增加 28-47%相关。此外，炎症性饮食模式的大量摄入与肾功能下降有关（男性β=-0.85，95%CI-1.26 至-0.43，女性β=-0.53，95%CI-0.98 至-0.08），并增加了两性的 N/L 和/或 CRP。总之，炎症性饮食模式与中年和老年肾功能下降者的血脂异常、贫血和肾功能下降呈正相关。
