Rezk Sherif A, Weiss Lawrence M
Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, 101 The City Drive, Orange, CA 92868, USA.
Department of Pathology and Laboratory Medicine, University of California Irvine (UCI) Medical Center, 101 The City Drive, Orange, CA 92868, USA; NeoGenomics Laboratories, 31 Columbia, Aliso Viejo, CA 92656, USA.
Surg Pathol Clin. 2019 Sep;12(3):745-770. doi: 10.1016/j.path.2019.03.002.
Although about 90% of the world's population is infected by EBV only a small subset of the related infections result in neoplastic transformation. EBV is a versatile oncogenic agent involved in a multitude of hematopoietic, epithelial, and mesenchymal neoplasms, but the precise role of EBV in the pathogenesis of many of the associated lymphoid/histiocytic proliferations remains hypothetical or not completely understood. Additional studies and use of evolving technologies such as high-throughput next-generation sequencing may help address this knowledge gap and may lead to enhanced diagnostic assessment and the development of potential therapeutic interventions.
尽管世界上约90%的人口感染了EB病毒，但只有一小部分相关感染会导致肿瘤转化。EB病毒是一种多功能致癌因子，涉及多种造血、上皮和间充质肿瘤，但EB病毒在许多相关淋巴样/组织细胞增殖发病机制中的精确作用仍属假设或尚未完全了解。更多的研究以及诸如高通量下一代测序等不断发展的技术的应用，可能有助于填补这一知识空白，并可能带来诊断评估的改进以及潜在治疗干预措施的开发。
