Research Department, Spine Centre of Southern Denmark, Middelfart, Denmark.
Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Scand J Rheumatol. 2020 Jan;49(1):21-27. doi: 10.1080/03009742.2019.1616324. Epub 2019 Jul 29.
: To describe the incidence of ankylosing spondylitis (AS) and spondyloarthritis (SpA) in the Danish population in 2000-2013, at national and regional level, and to investigate any trends in incidence over time.: From the Danish National Patient Registry (NPR), we identified patients diagnosed with AS (International Classification of Diseases, 10th revision: M45) or SpA (M46) from 1 January 2000 to 31 December 2013. Patients without a relevant contact in NPR at 12-24 months after initial diagnosis were excluded. Incidence rate ratios (IRRs) were calculated using the background population of men and women aged 18-45 years in 2000-2013 as a comparator. Variations in incidence between periods and the five Danish regions were evaluated.: In total, 3042 incident cases were identified (AS: 1849; SpA: 1193). AS incidence increased from 476 in 2000-2004 to 660 in 2010-2013; the IRR (95% confidence interval) increased from 1.49 (1.33-1.67) in 2005-2009 to 1.74 (1.53-1.97) in 2010-2013. SpA incidence increased from 156 in 2000-2004 to 707 in 2010-2013; the IRR increased from 2.45 (2.03-2.94) in 2005-2009 to 6.31 (5.27-7.55) in 2010-2013. The incidence of both AS and SpA increased in all five regions.: The incidence of both AS and SpA in Denmark increased from 2000 to 2013. However, the proportion of patients diagnosed with SpA rather than AS was significantly higher in 2010-2013. This may be due to increased awareness of SpA and new treatment options, but possibly also misclassification of patients with SpA.
：描述 2000-2013 年丹麦人群中强直性脊柱炎（AS）和脊柱关节炎（SpA）的发病率，在国家和地区层面，并调查发病率随时间的任何趋势。：我们从丹麦国家患者登记处（NPR）中确定了 2000 年 1 月 1 日至 2013 年 12 月 31 日期间被诊断为 AS（国际疾病分类，第 10 版：M45）或 SpA（M46）的患者。初始诊断后 12-24 个月内 NPR 中无相关联系的患者被排除在外。使用 2000-2013 年 18-45 岁男性和女性的背景人群计算发病率比（IRR）作为比较。评估不同时期和丹麦五个地区之间发病率的差异。：共确定了 3042 例新发病例（AS：1849 例；SpA：1193 例）。AS 的发病率从 2000-2004 年的 476 例增加到 2010-2013 年的 660 例；发病率比（95%置信区间）从 2005-2009 年的 1.49（1.33-1.67）增加到 2010-2013 年的 1.74（1.53-1.97）。SpA 的发病率从 2000-2004 年的 156 例增加到 2010-2013 年的 707 例；发病率比从 2005-2009 年的 2.45（2.03-2.94）增加到 2010-2013 年的 6.31（5.27-7.55）。AS 和 SpA 的发病率均在所有五个地区增加。：2000 年至 2013 年期间，丹麦的 AS 和 SpA 发病率均有所上升。然而，2010-2013 年被诊断为 SpA 而不是 AS 的患者比例明显更高。这可能是由于对 SpA 的认识提高和新的治疗选择，但也可能是 SpA 患者的误诊。
