Herrewegh A G M, Vrijens D M J, Marcelissen T A T, van Koeveringe G A
Department of Urology, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Scand J Urol. 2019 Aug;53(4):255-260. doi: 10.1080/21681805.2019.1641551. Epub 2019 Jul 29.
To investigate the differences in bladder sensations of overactive bladder (OAB) patients compared to healthy volunteers. In addition, to see if bladder sensations are different in men and women. In a prospective, longitudinal study (METC 09-2-095), 66 volunteers and 68 OAB patients were included. Anticholinergic medication was stopped. Subjects filled out a sensation-related bladder diary (SR-BD), for two periods of 3 days, including a 4-points urgency scale and visual analogue scale for perception of bladder fullness. In total, 6160 voids were assessed. Patients voided more often with higher degrees of urge at a lower mean voided volume (193 vs 270 ml/void; < 0.001) than healthy volunteers. The mean urinary frequency per litre diuresis was also higher (5.8 vs 4.1/l; < 0.001) in patients. At the same voided volume: patients perceived a higher mean bladder fullness, independent of the degree of urge, and higher urgency (1.4 vs 0.5/100 ml; < 0.001) than healthy volunteers. There were no gender differences in the above-mentioned voiding parameters, except for the mean voided volume at urge 3 in volunteers (340 ml in men vs 362 ml in women; = 0.03) and urge 1 in patients (171 ml in men vs 135 ml in women; = 0.027). Bladder sensations were significantly increased in everyday life for both male and female OAB patients compared to healthy volunteers. OAB patients experienced a higher mean bladder fullness sensation, independent of the degree of urge, and higher mean urge/urgency at the same voided volume than volunteers. Bladder sensations are crucial in the assessment of treatment response.
为研究膀胱过度活动症（OAB）患者与健康志愿者在膀胱感觉上的差异。此外，观察膀胱感觉在男性和女性中是否存在差异。在一项前瞻性纵向研究（METC 09 - 2 - 095）中，纳入了66名志愿者和68名OAB患者。停用抗胆碱能药物。受试者填写一份与感觉相关的膀胱日记（SR - BD），为期两个3天周期，包括一个4分制的尿急量表和膀胱充盈感知的视觉模拟量表。总共评估了6160次排尿。与健康志愿者相比，患者排尿更频繁，在较低的平均排尿量（193 vs 270 ml/次；<0.001）时尿急程度更高。患者每升利尿的平均排尿频率也更高（5.8 vs 4.1/升；<0.001）。在相同排尿量时：患者感觉到更高的平均膀胱充盈度，与尿急程度无关，并且比健康志愿者有更高的尿急感（1.4 vs 0.5/100 ml；<0.001）。除了志愿者在尿急3时的平均排尿量（男性为340 ml，女性为362 ml；P = 0.03）和患者在尿急1时的平均排尿量（男性为171 ml，女性为135 ml；P = 0.027）外，上述排尿参数不存在性别差异。与健康志愿者相比，男性和女性OAB患者在日常生活中的膀胱感觉均显著增强。OAB患者在相同排尿量时，感觉到更高的平均膀胱充盈感，与尿急程度无关，并且比志愿者有更高的平均尿急/紧迫感。膀胱感觉在治疗反应评估中至关重要。
