Takahashi M, Ushijima T, Ozaki Y
Department of Microbiology, Shiga University of Medical Science, Japan.
J Med Microbiol. 1988 Aug;26(4):281-4. doi: 10.1099/00222615-26-4-281.
Liver xanthine oxidase (XOD) and superoxide dismutase (SOD) activities were compared in mice during Salmonella typhimurium and Pseudomonas aeruginosa infections. We observed that XOD activity rose but SOD activity fell for the first 11 days after infection with smooth type S. typhimurium, coinciding with the period of bacterial growth in the liver. Rough type S. typhimurium did not establish an infection and mice inoculated with this strain showed no variation in enzyme activities. P. aeruginosa infection was mild but stimulated both XOD and SOD activities.
在鼠伤寒沙门氏菌和铜绿假单胞菌感染期间，对小鼠肝脏中的黄嘌呤氧化酶（XOD）和超氧化物歧化酶（SOD）活性进行了比较。我们观察到，在感染光滑型鼠伤寒沙门氏菌后的前11天，XOD活性升高而SOD活性下降，这与肝脏中细菌生长的时期一致。粗糙型鼠伤寒沙门氏菌未引发感染，接种该菌株的小鼠酶活性没有变化。铜绿假单胞菌感染较轻，但刺激了XOD和SOD的活性。
