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Use of levosimendan in acute and advanced heart failure: short review on available real-world data.左西孟旦在急性和晚期心力衰竭中的应用：基于现有真实世界数据的简短综述
Ther Clin Risk Manag. 2019 Jun 17;15:765-772. doi: 10.2147/TCRM.S188761. eCollection 2019.
2
The utility of levosimendan in the treatment of heart failure.左西孟旦在心力衰竭治疗中的应用
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Levosimendan: a review of its use in the management of acute decompensated heart failure.左西孟旦：急性失代偿性心力衰竭治疗应用综述
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Levosimendan: current status and future prospects.左西孟旦：现状与未来展望。
Curr Opin Anaesthesiol. 2008 Feb;21(1):78-84. doi: 10.1097/ACO.0b013e3282f357a5.

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Use of levosimendan combined with Shenfu injection to treat acute heart failure patients with hypotension: a prospective randomized controlled single-blind study.左西孟旦联合参附注射液治疗低血压急性心力衰竭患者的前瞻性随机对照单盲研究。
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本文引用的文献

1
Impact of levosimendan on weaning from peripheral venoarterial extracorporeal membrane oxygenation in intensive care unit.左西孟旦对重症监护病房中从外周静脉-动脉体外膜肺氧合撤机的影响。
Ann Intensive Care. 2019 Feb 1;9(1):24. doi: 10.1186/s13613-019-0503-1.
2
Repetitive levosimendan treatment in the management of advanced heart failure.重复使用左西孟旦治疗晚期心力衰竭
Eur Heart J Suppl. 2018 Dec;20(Suppl I):I11-I20. doi: 10.1093/eurheartj/suy040. Epub 2018 Nov 2.
3
Levosimendan in Acute and Advanced Heart Failure: an Expert Perspective on Posology and Therapeutic Application.左西孟旦在急性和晚期心力衰竭中的应用：剂量和治疗应用的专家观点。
Cardiovasc Drugs Ther. 2018 Dec;32(6):617-624. doi: 10.1007/s10557-018-6838-2.
4
Differential Effects of Levosimendan and Dobutamine on Glomerular Filtration Rate in Patients With Heart Failure and Renal Impairment:A Randomized Double-Blind Controlled Trial.左西孟旦和多巴酚丁胺对心力衰竭合并肾功能不全患者肾小球滤过率的影响：一项随机、双盲、对照试验。
J Am Heart Assoc. 2018 Aug 21;7(16):e008455. doi: 10.1161/JAHA.117.008455.
5
Ambulatory Inotrope Infusions in Advanced Heart Failure: A Systematic Review and Meta-Analysis.门诊儿茶酚胺输注治疗心力衰竭：系统评价和荟萃分析。
JACC Heart Fail. 2018 Sep;6(9):757-767. doi: 10.1016/j.jchf.2018.03.019. Epub 2018 Jul 11.
6
Levosimendan in pulmonary hypertension and right heart failure.左西孟旦治疗肺动脉高压和右心衰竭
Pulm Circ. 2018 Jul-Sep;8(3):2045894018790905. doi: 10.1177/2045894018790905. Epub 2018 Jul 6.
7
Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study.左西孟旦在治疗脑血管痉挛中的应用：一项病例研究。
Drug Des Devel Ther. 2018 Jun 20;12:1777-1783. doi: 10.2147/DDDT.S158237. eCollection 2018.
8
Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology.心力衰竭的治疗进展：欧洲心脏病学会心力衰竭协会立场声明。
Eur J Heart Fail. 2018 Nov;20(11):1505-1535. doi: 10.1002/ejhf.1236. Epub 2018 Jul 17.
9
Efficacy and safety of intermittent intravenous outpatient administration of levosimendan in patients with advanced heart failure: the LION-HEART multicentre randomised trial.左西孟旦静脉间歇输注治疗晚期心力衰竭患者的有效性和安全性：LION-HEART 多中心随机试验。
Eur J Heart Fail. 2018 Jul;20(7):1128-1136. doi: 10.1002/ejhf.1145. Epub 2018 Feb 6.
10
The potential of the inodilator levosimendan in maintaining quality of life in advanced heart failure.血管扩张剂左西孟旦在维持晚期心力衰竭患者生活质量方面的潜力。
Eur Heart J Suppl. 2017 Mar;19(Suppl C):C15-C21. doi: 10.1093/eurheartj/sux003. Epub 2017 Mar 8.

左西孟旦在急性和晚期心力衰竭中的应用：基于现有真实世界数据的简短综述

Use of levosimendan in acute and advanced heart failure: short review on available real-world data.

作者信息

Pashkovetsky Eugene, Gupta Chhaya Aggarwal, Aronow Wilbert S

机构信息

Division of Cardiology, Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.

出版信息

Ther Clin Risk Manag. 2019 Jun 17;15:765-772. doi: 10.2147/TCRM.S188761. eCollection 2019.

DOI:10.2147/TCRM.S188761
PMID:31354283
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6588712/
Abstract

Published data have shown potential advantages of levosimendan in the management of acute decompensated heart failure and advanced heart failure when standard medical therapies threaten hemodynamics and organ perfusion are unable to alleviate clinical symptoms. Levosimendan distinguishes itself from other catecholaminergic inotropes by its three mechanisms of action: positive inotropy, vasodilation, and cardioprotection. In addition, its pharmacokinetics allow for a longer duration of action from the metabolite OR1896 allowing for further cardiovascular therapeutic effects for several days, even after discontinuation of the parent drug.

摘要

已发表的数据表明，当标准药物治疗危及血流动力学且无法缓解临床症状时，左西孟旦在急性失代偿性心力衰竭和晚期心力衰竭的治疗中具有潜在优势。左西孟旦通过其三种作用机制区别于其他儿茶酚胺能强心剂：正性肌力作用、血管舒张作用和心脏保护作用。此外，其药代动力学特性使代谢产物OR1896的作用持续时间更长，即使在停用母体药物后，也能在数天内产生进一步的心血管治疗效果。