左西孟旦在急性和晚期心力衰竭中的应用：基于现有真实世界数据的简短综述
Use of levosimendan in acute and advanced heart failure: short review on available real-world data.
作者信息
Pashkovetsky Eugene, Gupta Chhaya Aggarwal, Aronow Wilbert S
机构信息
Division of Cardiology, Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595, USA.
出版信息
Ther Clin Risk Manag. 2019 Jun 17;15:765-772. doi: 10.2147/TCRM.S188761. eCollection 2019.
Abstract
Published data have shown potential advantages of levosimendan in the management of acute decompensated heart failure and advanced heart failure when standard medical therapies threaten hemodynamics and organ perfusion are unable to alleviate clinical symptoms. Levosimendan distinguishes itself from other catecholaminergic inotropes by its three mechanisms of action: positive inotropy, vasodilation, and cardioprotection. In addition, its pharmacokinetics allow for a longer duration of action from the metabolite OR1896 allowing for further cardiovascular therapeutic effects for several days, even after discontinuation of the parent drug.
摘要
已发表的数据表明，当标准药物治疗危及血流动力学且无法缓解临床症状时，左西孟旦在急性失代偿性心力衰竭和晚期心力衰竭的治疗中具有潜在优势。左西孟旦通过其三种作用机制区别于其他儿茶酚胺能强心剂：正性肌力作用、血管舒张作用和心脏保护作用。此外，其药代动力学特性使代谢产物OR1896的作用持续时间更长，即使在停用母体药物后，也能在数天内产生进一步的心血管治疗效果。
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