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Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies.社论：人类疾病中的肽基脯氨酰异构酶
Front Pharmacol. 2019 Jul 11;10:794. doi: 10.3389/fphar.2019.00794. eCollection 2019.
2
Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases.肽基脯氨酰顺反异构酶：心血管疾病中的关键角色。
Cardiovasc Res. 2015 Jun 1;106(3):353-64. doi: 10.1093/cvr/cvv096. Epub 2015 Mar 5.
3
Computational perspective and evaluation of plausible catalytic mechanisms of peptidyl-prolyl cis-trans isomerases.肽基脯氨酰顺反异构酶可能的催化机制的计算视角与评估
Biochim Biophys Acta. 2015 Oct;1850(10):1994-2004. doi: 10.1016/j.bbagen.2014.12.023. Epub 2015 Jan 10.
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The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells.微管靶向剂PBOX-6 [吡咯并苯并恶嗪7-[(二甲基氨基甲酰基)氧基]-6-(2-萘基)吡咯并-[2,1-d](1,5)-苯并恶嗪] 和紫杉醇可诱导恶性造血细胞中肽基脯氨酰异构酶亲环蛋白A和Pin1的核质再分布。
J Pharmacol Exp Ther. 2009 Apr;329(1):38-47. doi: 10.1124/jpet.108.148130. Epub 2009 Jan 8.
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A novel peptidyl-prolyl cis/trans isomerase from Escherichia coli.一种来自大肠杆菌的新型肽基脯氨酰顺/反异构酶。
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Inhibition of peptidyl-prolyl cis/trans isomerase activity by substrate analog structures: thioxo tetrapeptide-4-nitroanilides.底物类似物结构对肽基脯氨酰顺/反异构酶活性的抑制作用：硫代四肽-4-硝基苯胺
Biochemistry. 1995 Oct 10;34(40):13016-26. doi: 10.1021/bi00040a012.
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Peptidyl-prolyl cis-trans isomerase improves the efficiency of protein disulfide isomerase as a catalyst of protein folding.肽基脯氨酰顺反异构酶提高了蛋白质二硫键异构酶作为蛋白质折叠催化剂的效率。
Proc Natl Acad Sci U S A. 1992 May 15;89(10):4510-3. doi: 10.1073/pnas.89.10.4510.
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Microbial cyclophilins: specialized functions in virulence and beyond.微生物亲环素：在毒力及其他方面的特殊功能
World J Microbiol Biotechnol. 2017 Aug 8;33(9):164. doi: 10.1007/s11274-017-2330-6.
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Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease.肽基脯氨酰异构酶：心血管疾病中的功能及潜在治疗靶点
Clin Exp Pharmacol Physiol. 2015 Feb;42(2):117-24. doi: 10.1111/1440-1681.12335.
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Amino acid sequence of peptidyl-prolyl isomerase a of Fusarium sporotrichioides.拟枝孢镰刀菌肽基脯氨酰顺反异构酶a的氨基酸序列
Nat Toxins. 1996;4(4):149-55. doi: 10.1002/19960404nt1.

本文引用的文献

1
Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects.虚拟筛选鉴定出一种可能具有抗卵巢癌作用的PIN1抑制剂。
J Cell Physiol. 2019 Sep;234(9):15708-15716. doi: 10.1002/jcp.28224. Epub 2019 Jan 29.
2
PrsA2 (CD630_35000) of Is an Active Parvulin-Type PPIase and a Virulence Modulator.PrsA2（CD630_35000）是一种活性细小菌素型肽脯氨酰顺反异构酶和毒力调节剂。
Front Microbiol. 2018 Dec 4;9:2913. doi: 10.3389/fmicb.2018.02913. eCollection 2018.
3
Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer.用与环糊精复合的 Pin1 抑制剂的脂质体递送来治疗高级别浆液性卵巢癌的新疗法。
J Control Release. 2018 Jul 10;281:1-10. doi: 10.1016/j.jconrel.2018.04.055. Epub 2018 May 8.
4
Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Toxin.药理环孢菌素抑制剂可预防毒素对哺乳动物细胞的中毒。
Toxins (Basel). 2018 May 1;10(5):181. doi: 10.3390/toxins10050181.
5
The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27.肽基脯氨酰顺反异构酶 PIN1 通过使 CDK 抑制剂 p27 失活来解除细胞周期蛋白依赖性激酶 2（CDK2）的抑制。
J Biol Chem. 2017 Dec 29;292(52):21431-21441. doi: 10.1074/jbc.M117.801373. Epub 2017 Nov 8.
6
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.一种共价型 PIN1 抑制剂通过双重作用机制选择性地靶向癌细胞。
Nat Commun. 2017 Jun 9;8:15772. doi: 10.1038/ncomms15772.
7
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.活化的Pin1是全反式维甲酸在急性早幼粒细胞白血病和乳腺癌中的关键靶点。
Nat Med. 2015 May;21(5):457-66. doi: 10.1038/nm.3839. Epub 2015 Apr 13.
8
Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases.肽基脯氨酰顺反异构酶：心血管疾病中的关键角色。
Cardiovasc Res. 2015 Jun 1;106(3):353-64. doi: 10.1093/cvr/cvv096. Epub 2015 Mar 5.
9
Prolyl isomerization and its catalysis in protein folding and protein function.脯氨酰异构化及其在蛋白质折叠和功能中的催化作用。
J Mol Biol. 2015 Apr 10;427(7):1609-31. doi: 10.1016/j.jmb.2015.01.023. Epub 2015 Feb 9.
10
The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease.肽基脯氨酰异构酶伴侣蛋白在tau蛋白寡聚化、淀粉样蛋白加工及阿尔茨海默病中的新作用
J Neurochem. 2015 Apr;133(1):1-13. doi: 10.1111/jnc.13033. Epub 2015 Feb 24.

Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies.

作者信息

Tuccinardi Tiziano, Rizzolio Flavio

机构信息

Department of Pharmacy, University of Pisa, Pisa, Italy.

Department of Translational Research, Pathology Unit, National Cancer Institute-CRO-IRCSS, Aviano, Italy.

出版信息

Front Pharmacol. 2019 Jul 11;10:794. doi: 10.3389/fphar.2019.00794. eCollection 2019.

DOI:10.3389/fphar.2019.00794
PMID:31354501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6637298/
Abstract
摘要