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Editorial: Peptidyl-Prolyl Isomerases in Human Pathologies.

作者信息

Tuccinardi Tiziano, Rizzolio Flavio

机构信息

Department of Pharmacy, University of Pisa, Pisa, Italy.

Department of Translational Research, Pathology Unit, National Cancer Institute-CRO-IRCSS, Aviano, Italy.

出版信息

Front Pharmacol. 2019 Jul 11;10:794. doi: 10.3389/fphar.2019.00794. eCollection 2019.

Abstract
摘要

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Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects.
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The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27.
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Peptidyl-prolyl isomerases: a full cast of critical actors in cardiovascular diseases.
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Prolyl isomerization and its catalysis in protein folding and protein function.
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