Fischer J H, Barr A N, Paloucek F P, Dorociak J V, Spunt A L
Clinical Pharmacokinetics Laboratory, College of Pharmacy, University of Illinois, Chicago 60612.
Neurology. 1988 Aug;38(8):1319-22. doi: 10.1212/wnl.38.8.1319.
We evaluated the effect of food on the serum concentration profile of enteric-coated divalproex sodium (EC-VPA) in six adult volunteers following a single dose and in six patients during chronic-dose administration. The results demonstrated a significant delay but no decrease in extent of EC-VPA absorption following administration with food. To monitor serum concentrations in patients receiving EC-VPA, consideration of sampling time in relation both to time of dose and meals is required.
