Fortpied Catherine, Vinches Marie
EORTC Headquarters, Brussels, Belgium.
Front Oncol. 2019 Jul 12;9:634. doi: 10.3389/fonc.2019.00634. eCollection 2019.
The purpose of this article is two-fold: to help statisticians confronted with the design, implementation and analysis of clinical trials and new to the field of head and neck cancer; but also to sensitize research physicians with the role, the tasks and the challenges faced by the medical statisticians. These two purposes altogether will hopefully encourage and enable fluid communication between the research physician and the medical statistician and the understanding of each other's field and concerns. In particular, the methodological challenges resulting from the heterogeneity of the head and neck cancer, the complexity of the treatments and the associated comorbidities are presented with examples borrowed from medical literature and from the practical experience of the authors in this field.
帮助初涉头颈癌领域、面临临床试验设计、实施和分析的统计学家；同时让研究医师了解医学统计学家的角色、任务以及所面临的挑战。希望这两个目的能共同促进研究医师和医学统计学家之间的顺畅沟通，增进对彼此领域和关注点的理解。特别是，本文通过借鉴医学文献以及作者在该领域的实践经验中的实例，阐述了由于头颈癌的异质性、治疗的复杂性以及相关合并症所带来的方法学挑战。
