CYP17A1 多态性与病例对照研究中心血管疾病风险相关。

CYP17A1 Polymorphisms Are Linked to the Risk of Coronary Heart Disease in a Case-Control Study.

机构信息

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha, China.

出版信息

J Cardiovasc Pharmacol. 2019 Aug;74(2):98-104. doi: 10.1097/FJC.0000000000000687.

DOI:10.1097/FJC.0000000000000687

PMID:31356544

Abstract

BACKGROUND

Cytochrome P450 17A1 (CYP17A1) catalyzes the formation and metabolism of steroid hormones and is required for cortisol and androgens. There is increasing evidence that CYP17A1 plays an important role in the development of coronary heart disease (CHD). However, the association of CYP17A1 polymorphisms and CHD susceptibility is still not clear.

METHODS

We conducted a case-control study with 396 CHD cases and 461 healthy controls from Hainan province, China. Using the Agena MassARRAY platform, we genotyped 4 genetic variants (rs3740397, rs1004467, rs4919687, and rs3781286) in CYP17A1. Logistic regression analysis was used to assess the association of CYP17A1 polymorphisms with CHD risk by odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS

It showed that A allele of CYP17A1 rs4919687 carried with a 1.59-fold increased risk of CHD (OR = 1.59; 95% CI = 1.26-1.99; P < 0.001). Also, rs4919687 was significantly associated with CHD risk under various models (homozygote: OR = 3.60; 95% CI = 1.64-7.83; P = 0.001; dominant: OR = 1.51; 95% CI = 1.06-2.13; P = 0.021; recessive: OR = 3.28; 95% CI = 1.51-7.14; P = 0.003; additive: OR = 1.56; 95% CI = 1.17-2.07; P = 0.002). Moreover, analysis showed that Ars1004467 Ars4919687 haplotype was a protective factor of CHD (OR = 0.64; 95% CI = 0.48-0.86; P = 0.002).

CONCLUSIONS

Our study suggests that CYP17A1 polymorphisms are associated with CHD susceptibility in the Hainan Han Chinese population.

摘要

背景

细胞色素 P450 17A1（CYP17A1）催化甾体激素的形成和代谢，是皮质醇和雄激素所必需的。越来越多的证据表明，CYP17A1 在冠心病（CHD）的发展中起着重要作用。然而，CYP17A1 多态性与 CHD 易感性的关联尚不清楚。

方法

我们进行了一项病例对照研究，共纳入 396 例 CHD 病例和 461 例健康对照，来自中国海南省。使用 Agena MassARRAY 平台，我们对 CYP17A1 中的 4 种遗传变异（rs3740397、rs1004467、rs4919687 和 rs3781286）进行了基因分型。采用 logistic 回归分析评估 CYP17A1 多态性与 CHD 风险的关联，以比值比（ORs）和 95%置信区间（CIs）表示。

结果

结果表明，CYP17A1 rs4919687 的 A 等位基因使 CHD 的风险增加 1.59 倍（OR = 1.59；95%CI = 1.26-1.99；P < 0.001）。此外，rs4919687 在各种模型下与 CHD 风险显著相关（纯合子：OR = 3.60；95%CI = 1.64-7.83；P = 0.001；显性：OR = 1.51；95%CI = 1.06-2.13；P = 0.021；隐性：OR = 3.28；95%CI = 1.51-7.14；P = 0.003；加性：OR = 1.56；95%CI = 1.17-2.07；P = 0.002）。此外，分析表明 Ars1004467 Ars4919687 单倍型是 CHD 的保护因素（OR = 0.64；95%CI = 0.48-0.86；P = 0.002）。