Department of Internal Medicine, Rady School of Medicine, University of Manitoba, Winnipeg, MB, Canada.
J Clin Gastroenterol. 2019 Sep;53(8):553-559. doi: 10.1097/MCG.0000000000001243.
There is increasing concern among patients and health care providers about the associations between PPI use and a multitude of potential adverse outcomes. Therefore, clinicians need to have a rational approach both to identifying PPI users who may not have an ongoing indication for their use and on how to encourage discontinuation of unnecessary PPI use. In this paper, we will provide a detailed review of the specific indications where the benefits of ongoing PPI use is of questionable value and will review the evidence on how to maximize the likelihood of being able to successfully discontinue PPI use while minimizing symptom recurrence.
越来越多的患者和医疗保健提供者对质子泵抑制剂 (PPI) 使用与多种潜在不良后果之间的关联表示担忧。因此，临床医生需要采取合理的方法，既要识别出那些可能不再需要继续使用 PPI 的患者，也要确定如何鼓励他们停止不必要的 PPI 使用。在本文中，我们将详细回顾那些持续使用 PPI 获益值得怀疑的具体适应证，并回顾有关如何最大限度地提高成功停用 PPI 的可能性，同时最大限度地减少症状复发的证据。
