Hein J, Wiersbitzky S, Wunderlich P
Klinik für Kinderheilkunde der Wilhelm-Pieck-Universität Rostock, DDR.
Z Erkr Atmungsorgane. 1988;170(2):201-11.
Cystic fibrosis (CF) is the most common genetic disease of Caucasians and also the most important lung disease of the first decades of life associated with infections by a variety of bacteria species especially Pseudomonas aeruginosa and Staphylococcus aureus. During the last two decades chronic Pseudomonas infection has emerged as the most difficult problem. Pseudomonas bacteria are able to synthesize numerous extracellular factors (virulence factors) contributing to its pathogenicity. Immunological defense mechanisms against Pseudomonas (and other bacteria species) have been demonstrated, but a complete elimination from infected lungs has not been observed. Therapy of Pseudomonas infections includes frequently combinations of antibiotics of the beta-lactam and aminoglycoside type.
囊性纤维化（CF）是白种人中最常见的遗传性疾病，也是生命最初几十年中最重要的肺部疾病，与多种细菌感染有关，尤其是铜绿假单胞菌和金黄色葡萄球菌。在过去二十年中，慢性铜绿假单胞菌感染已成为最棘手的问题。铜绿假单胞菌能够合成多种有助于其致病性的细胞外因子（毒力因子）。针对铜绿假单胞菌（及其他细菌种类）的免疫防御机制已得到证实，但尚未观察到从感染肺部完全清除该菌的情况。铜绿假单胞菌感染的治疗通常包括β-内酰胺类和氨基糖苷类抗生素联合使用。
