Tirelli U, Vaccher E, Ambrosini A, Andriani A, Bianco Silvestroni I, Broccia G, Chisesi T, Dessalvi P, Gobbi M, Fassio F
Division of Medical Oncology, Centro di Riferimento Oncologico, Aviano, Italy.
Acta Haematol. 1988;80(1):49-51. doi: 10.1159/000205597.
We report 36 patients with non-Hodgkin's lymphomas (NHL) and 10 patients with Hodgkin's disease (HD), predominantly intravenous drug abusers (IVDA; 35 patients), diagnosed in 16 different Italian centers. The group of NHL has a median age of 26 years (range 16-64): 26 were IVDA, 3 polytransfused, 3 IVDA and homosexual men, 2 homosexual men and 2 without apparent risk for AIDS but carrying HIV antibodies. 81% of the evaluable patients had high-grade NHL (32% Burkitt's type) according to the Working Formulation, 15% intermediate and 4% low-grade. Out of 23 patients with stage reported, 16 (70%) were stage IV, 2 (9%) stage III, 1 (4%) stage II and 4 (17%) stage I (CNS involvement). The group with HD has a median age of 25 years (range 20-40), 9 were IVDA and 1 IVDA and homosexual. Of the 7 patients with subtype reported, 4 patients had nodular sclerosis and 3 mixed cellularity subtype. Stage III and IV were reported in 66% of the patients. The median survival is 4 months for NHL and 10 months for HD. The most common cause of death is opportunistic infection in 86% of the evaluable cases.
我们报告了36例非霍奇金淋巴瘤（NHL）患者和10例霍奇金病（HD）患者，这些患者主要为静脉吸毒者（IVDA；35例），由意大利16个不同中心诊断出来。NHL组的中位年龄为26岁（范围16 - 64岁）：26例为IVDA，3例多次输血，3例为IVDA且是同性恋男性，2例为同性恋男性，2例无明显艾滋病风险但携带HIV抗体。根据工作分类法，81%的可评估患者患有高级别NHL（32%为伯基特型），15%为中级，4%为低级别。在报告分期的23例患者中，16例（70%）为IV期，2例（9%）为III期，1例（4%）为II期，4例（17%）为I期（中枢神经系统受累）。HD组的中位年龄为25岁（范围20 - 40岁），9例为IVDA，1例为IVDA且是同性恋。在报告亚型的7例患者中，4例为结节硬化型，3例为混合细胞型。66%的患者报告为III期和IV期。NHL的中位生存期为4个月，HD为10个月。在86%的可评估病例中，最常见的死亡原因是机会性感染。
