Cheng Hao, Zhou Zhengyuan, Li Yanqing, Huang Wenyi, Feng Jun, Tang Tingfan, Li Lijun
Guangxi Key Laboratory of Green Processing of Sugar Resources, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, Guangxi, China.
Province and Ministry Co-Sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning 530004, Guangxi, China.
Sensors (Basel). 2019 Jul 28;19(15):3315. doi: 10.3390/s19153315.
The detection of difenidol hydrochloride, which is a drug that is widely used for treating the nausea and vomiting symptoms caused by certain diseases, has been increasingly involved in cases of suicide via overdosing and of drug poisoning in children. A novel electrochemiluminescence (ECL) sensor for the simple and effective detection of difenidol hydrochloride was fabricated by modifying a glassy carbon electrode with three-dimensional carbon nanofibers (3D-CNFs). The 3D-CNFs were synthesized by electrospinning a mixture of montmorillonite (MMT) and polyacrylonitrile, carbonizing the electrospun product, and etching it with hydrofluoric acid. The form and structure of the 3D-CNFs was analyzed via scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman microspectroscopy. According to the experimental results obtained using the modified electrodes, a good linear relationship was found between peak intensity and difenidol concentration (y = 868.14x - 61.04, R = 0.999), with a relatively low detection limit (8.64 × 10 mol·L (S/N = 3)). In addition, our approach exhibited good recovery values ranging from 98.99% to 102.28%. The proposed novel ECL sensor has wide application prospects for the detection of difenidol hydrochloride.
盐酸地芬尼多是一种广泛用于治疗某些疾病引起的恶心和呕吐症状的药物，其检测越来越多地涉及过量服用自杀案件和儿童药物中毒事件。通过用三维碳纳米纤维（3D-CNFs）修饰玻碳电极，制备了一种用于简单有效检测盐酸地芬尼多的新型电化学发光（ECL）传感器。3D-CNFs是通过静电纺丝蒙脱石（MMT）和聚丙烯腈的混合物、碳化静电纺丝产物并用氢氟酸蚀刻而合成的。通过扫描电子显微镜、X射线光电子能谱和拉曼光谱对3D-CNFs的形态和结构进行了分析。根据使用修饰电极获得的实验结果，发现峰强度与盐酸地芬尼多浓度之间存在良好的线性关系（y = 868.14x - 61.04，R = 0.999），检测限相对较低（8.64×10 mol·L（S/N = 3））。此外，我们的方法显示出良好的回收率，范围为98.99%至102.28%。所提出的新型ECL传感器在盐酸地芬尼多检测方面具有广阔的应用前景。
