Yang X, An D J, Gao C C, Qin H Y
Department of Medical Genetics and Developmental Biology, School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China.
Zhonghua Gan Zang Bing Za Zhi. 2019 Jun 20;27(6):477-480. doi: 10.3760/cma.j.issn.1007-3418.2019.06.019.
Cylindromatosis gene is a kind of tumor suppressor genes, whose mutation or deletion will lead to the development of a cylindrical tumor. The deubiquitinating enzyme CYLD protein encoded by it is a member of the deubiquitinating enzyme family. CYLD alters the function of the target molecules by removing the ubiquitin chain linked to the substrate protein K63, and participates in the regulation of signaling pathways, such as NF-κB, JNK and Wnt. This article reviews the recent year's research progress of CYLD, especially its negative regulatory role in the progression of liver-related diseases.
圆柱瘤病基因是一种肿瘤抑制基因，其突变或缺失会导致圆柱瘤的发生。由它编码的去泛素化酶CYLD蛋白是去泛素化酶家族的成员。CYLD通过去除与底物蛋白K63相连的泛素链来改变靶分子的功能，并参与NF-κB、JNK和Wnt等信号通路的调控。本文综述了近年来CYLD的研究进展，特别是其在肝脏相关疾病进展中的负调控作用。
