Loughran T P, Starkebaum G, Ruscetti F W
Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Blood. 1988 Aug;72(2):613-5.
We established interleukin-2-(IL-2) dependent cell lines from three patients with large granular lymphocyte (LGL) leukemia. Phenotypic analysis demonstrated retention of the CD3+, CD8+ phenotype that was observed in the original leukemic LGL. Unique rearrangements of T-cell receptor beta gene occurring in uncultured leukemic LGL, were also found in cell lines, which suggests that the cell lines were derived from the original leukemic LGL clone in each case.
我们从三名大颗粒淋巴细胞（LGL）白血病患者中建立了白细胞介素-2（IL-2）依赖细胞系。表型分析显示，这些细胞系保留了原始白血病LGL中观察到的CD3 +、CD8 +表型。在未培养的白血病LGL中发生的T细胞受体β基因独特重排，在细胞系中也被发现，这表明在每种情况下，细胞系均源自原始白血病LGL克隆。
