实施益生菌方案以降低坏死性小肠结肠炎的发生率。
Implementation of a probiotic protocol to reduce rates of necrotizing enterocolitis.
机构信息
Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Data Science Services, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
J Perinatol. 2019 Sep;39(9):1315-1322. doi: 10.1038/s41372-019-0443-5. Epub 2019 Jul 29.
OBJECTIVE
To utilize a probiotic protocol to achieve a 50% reduction in rates of necrotizing enterocolitis (NEC) ≥ Bell Stage 2 within 2 years of protocol implementation.
STUDY DESIGN
Literature review guided probiotic selection and protocol design. A driver diagram identified key drivers to achieve our aim. A U chart followed monthly NEC ≥ Bell Stage 2 per 100 patient days and per monthly admissions. The process measure was protocol compliance and the balancing measure was probiotic sepsis.
RESULTS
NEC ≥ Bell Stage 2 decreased from 0.14 to 0.04 per 100 patient days in infants < 33 weeks gestation or <1500 g, or a yearly rate of 7-2%. Protocol compliance was 98% and there were no cases of probiotic sepsis.
CONCLUSION
Implementation of a probiotic protocol was associated with a decrease in rates of NEC.
目的
利用益生菌方案，在方案实施后 2 年内，将≥贝尔 2 期坏死性小肠结肠炎（NEC）的发生率降低 50%。
研究设计
文献综述指导益生菌的选择和方案设计。驱动图确定了实现目标的关键驱动因素。U 图表每月跟踪每 100 个患者日和每月入院 NEC≥贝尔 2 期的发病率。过程测量是方案依从性，平衡测量是益生菌败血症。
结果
在胎龄<33 周或体重<1500 克的婴儿中，NEC≥贝尔 2 期的发病率从每 100 个患者日的 0.14 降至 0.04，即每年的发病率为 7-2%。方案依从性为 98%，且无益生菌败血症病例。
结论
益生菌方案的实施与 NEC 发生率的降低有关。
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