Section of Virology, Department of Medicine, Imperial College London, London, UK.
Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham, UK.
Nat Microbiol. 2019 Dec;4(12):2035-2038. doi: 10.1038/s41564-019-0517-3. Epub 2019 Jul 29.
Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.
蝙蝠流感 H17N10 病毒的血凝素和神经氨酸酶表面糖蛋白既不与唾液酸受体结合也不裂解它们，表明该病毒采用的细胞进入机制与经典的甲型流感病毒不同。我们观察到某些人类造血癌细胞系和犬 MDCK II 细胞容易被 H17 假型病毒感染。我们确定了人类 HLA-DR 受体是 H17 假型的进入介体，表明 H17N10 具有人畜共患病的潜力。
