[Neuroendocrine tumors : Classification, clinical presentation and imaging].

CONTEXT

Neuroendocrine tumors (NET) are a heterogeneous group of neoplasms found in all organs. They often present with characteristic clinical syndromes due to hormone hypersecretion.

DIAGNOSTICS

In addition to hormone diagnostics molecular-genetic work-up can play an important role.

IMAGING

Morphological imaging comprises ultrasound, endoscopy, computed tomography (CT) and magnetic resonance imaging (MRI) scans. Functional imaging of NET relies on radioligands that bind to specific receptors or transporters (Ga-68-DOTATATE-PET-CT, Tc-99-tektrotyd-SPECT/CT, F‑18-DOPA-PET/CT).

THERAPY

Somatostatin analogs either native or coupled to radionuclides are potent drugs for treating various neuroendocrine tumors.

CONCLUSION

The requirements of imaging are determined by clinical presentation, laboratory findings, tumor stage, the presence of a tumor syndrome and the need of a personalized systemic treatment modality.