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[中药胶剂质量控制方法的研究进展]

[Research progress on quality control methods of traditional Chinese medicine glues].

作者信息

Li Wen-Long, Zhang Yan, Liu Hai-Bin, Sun Yin-Hong, Zhou Xiang-Shan, Qu Hai-Bin

机构信息

College of Pharmaceutical Engineering of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine Tianjin 300193,China.

Pharmaceutical Informatics Institute,Zhejiang University Hangzhou 310058,China Dong-E Ejiao Co.,Ltd.,National Engineering Research Center for Gelatin-based Traditional Chinese Medicine Liaocheng 252201,China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2019 Jul;44(13):2748-2752. doi: 10.19540/j.cnki.cjcmm.20190321.306.

Abstract

Traditional Chinese medicine( TCM) glues,including leather glues,horn glues,nail glues and bone glues,have a long application history and unique characteristics. In recent years,their market demand has increased year by year because of their remarkable curative efficacy and nourishing effects,which leads to insufficient supply of raw material resources,and widespread use of fake and inferior products,seriously affecting the reputation of TCM glues and drug safety. In this context,the establishment of a more specific quality detection method for the TCM glues according to their specific characteristics can effectively improve the quality control level,promote rational use,and have a far-reaching impact on the industrial development of TCM glues. In this paper,the classification of TCM glues,as well as the production and application status of their representative( Ejiao) were briefly introduced; the papers on quality control technologies of TCM glues,including traditional identification experience,authenticity identification,physical property determination,protein,peptide and amino acid contents determination,element analysis,biological evaluation,and brand protection technology of TCM glues,were reviewed,and their advantages and disadvantages were summarized and analyzed comprehensively.Based on the specific characteristics of TCM glues,such as complex material basis,unclear pharmacodynamic components and different production processes,it was proposed in this paper to research and develop information-rich,convenient,fast,and non-destructive analytical techniques for the quality control of TCM glues and brand protection of famous products,thus promoting the healthy development of TCM glues industry.

摘要

传统中药胶,包括皮胶、角胶、甲胶和骨胶等,具有悠久的应用历史和独特的特性。近年来,因其显著的疗效和滋补作用,市场需求逐年增加,导致原料资源供应不足,假冒伪劣产品泛滥,严重影响了中药胶的声誉和用药安全。在此背景下,根据中药胶的具体特性建立更具针对性的质量检测方法,能够有效提高质量控制水平,促进合理用药,对中药胶产业发展具有深远影响。本文简要介绍了中药胶的分类及其代表性产品(阿胶)的生产与应用现状;综述了中药胶质量控制技术方面的文献,包括传统鉴别经验、真伪鉴别、物理性质测定、蛋白质、多肽及氨基酸含量测定、元素分析、生物学评价以及中药胶的品牌保护技术等,并全面总结分析了其优缺点。基于中药胶物质基础复杂、药效成分不明确、生产工艺各异等具体特性,本文提出研发信息丰富、便捷、快速且无损的分析技术用于中药胶的质量控制和名品品牌保护,从而推动中药胶产业健康发展。

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