[羧基-¹⁴C]邻氨基苯甲酸的代谢。I. 放射性掺入烟酰胺腺嘌呤二核苷酸（NAD⁺）和烟酰胺腺嘌呤二核苷酸磷酸（NADP⁺）。
The metabolism of [carboxyl-14C]anthranilic acid. I. The incorporation of radioactivity into NAD+ and NADP+.
作者信息
Ueda T, Otsuka H, Goda K, Ishiguro I, Naito J, Kotake Y
出版信息
J Biochem. 1978 Sep;84(3):687-96. doi: 10.1093/oxfordjournals.jbchem.a132174.
A new pathway of NAD+ synthesis from anthranilic acid was found in the livers of rats. Starting from [carboxyl-14C]anthranilic acid, radioactive NAD+ and NADP+ were produced as judged by Dowex-1 X 8-formate column chromatography followed by radiochromatography. Several intermediate compounds, such as quinolinic acid, nicotinic acid mononucleotide, and nicotinic acid adenine dinucleotide were also identified with the aid of various chromatographic techniques. In the experiments with liver microsomal hydroxylation systems, anthranilic acid was converted into not only 5-hydroxyanthranilic acid but also 3-hydroxyanthranilic acid.
在大鼠肝脏中发现了一条从邻氨基苯甲酸合成NAD⁺的新途径。以[羧基-¹⁴C]邻氨基苯甲酸为起始原料，经Dowex-1 X 8-甲酸盐柱色谱后再进行放射色谱分析判断，产生了放射性的NAD⁺和NADP⁺。借助各种色谱技术还鉴定出了几种中间化合物，如喹啉酸、烟酰胺单核苷酸和烟酰胺腺嘌呤二核苷酸。在肝脏微粒体羟基化系统的实验中，邻氨基苯甲酸不仅转化为5-羟基邻氨基苯甲酸，还转化为3-羟基邻氨基苯甲酸。
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