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造血干细胞移植患者中星状病毒MLB2的多样变体以及该病毒的进化速率和模式

Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus.

作者信息

Guo Ke, Li Li-Li, Zhang Qing, Yu Jie-Mei, Ye Yan

机构信息

Department of Immunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Department of Diarrhea, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China.

出版信息

Evol Bioinform Online. 2019 Jul 16;15:1176934319864922. doi: 10.1177/1176934319864922. eCollection 2019.

DOI:10.1177/1176934319864922
PMID:31360058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6637835/
Abstract

We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diversified variants and a strong positive selection in the patient, indicating that such patients may be a reservoir for astrovirus. The time to the most recent common ancestor of MLB2 and classic HAstVs was around 1800 years, and it has a decline in effective population size of HAstVs in the late 100 years.

摘要

我们评估了造血干细胞移植后免疫功能低下患者中人类星状病毒MLB2（HAstV-MLB2-YJMGK）的准种异质性，并对全球流行的HAstV分离株进行了遗传和进化分析。结果显示，该病毒在患者体内具有多样化的变异体且存在强烈的正选择，表明此类患者可能是星状病毒的储存宿主。MLB2与经典HAstV的最近共同祖先时间约为1800年，且在过去100年中HAstV的有效种群大小有所下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/859bebed7632/10.1177_1176934319864922-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/1d3c61adad4f/10.1177_1176934319864922-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/422dab4275b9/10.1177_1176934319864922-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/6c6380284207/10.1177_1176934319864922-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/859bebed7632/10.1177_1176934319864922-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/1d3c61adad4f/10.1177_1176934319864922-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/422dab4275b9/10.1177_1176934319864922-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/6c6380284207/10.1177_1176934319864922-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fe5/6637835/859bebed7632/10.1177_1176934319864922-fig4.jpg

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本文引用的文献

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Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian children.在发热的坦桑尼亚儿童血清中检测新型星状病毒MLB1和MLB2。
Emerg Microbes Infect. 2018 Mar 14;7(1):27. doi: 10.1038/s41426-018-0025-1.
2
Persistent Infections with Diverse Co-Circulating Astroviruses in Pediatric Oncology Patients, Memphis, Tennessee, USA.美国田纳西州孟菲斯市儿科肿瘤患者中多种共同传播的星状病毒持续感染
Emerg Infect Dis. 2017 Feb;23(2):288-290. doi: 10.3201/eid2302.161436.
3
Viral metagenomics of fecal samples from non-human primates revealed human astrovirus in a chimpanzee, China.
对来自中国一只黑猩猩的非人灵长类动物粪便样本进行的病毒宏基因组学研究发现了人星状病毒。
Gut Pathog. 2016 Nov 8;8:53. doi: 10.1186/s13099-016-0140-2. eCollection 2016.
4
Astrovirus MLB2, a New Gastroenteric Virus Associated with Meningitis and Disseminated Infection.星状病毒MLB2，一种与脑膜炎和播散性感染相关的新型胃肠病毒。
Emerg Infect Dis. 2016 May;22(5):846-53. doi: 10.3201/eid2205.151807.
5
A novel hepatovirus identified in wild woodchuck Marmota himalayana.在野生喜马拉雅旱獭（Marmota himalayana）中鉴定出一种新型肝炎病毒。
Sci Rep. 2016 Feb 29;6:22361. doi: 10.1038/srep22361.
6
Analysis of the ORF2 of human astroviruses reveals lineage diversification, recombination and rearrangement and provides the basis for a novel sub-classification system.对人类星状病毒ORF2的分析揭示了谱系多样化、重组和重排，并为一种新的亚分类系统提供了基础。
Arch Virol. 2014 Dec;159(12):3185-96. doi: 10.1007/s00705-014-2153-9. Epub 2014 Oct 19.
7
RNA populations in immunocompromised patients as reservoirs for novel norovirus variants.免疫功能低下患者体内的RNA群体作为新型诺如病毒变体的储存库。
J Virol. 2014 Dec;88(24):14184-96. doi: 10.1128/JVI.02494-14. Epub 2014 Oct 1.
8
Recombination analysis based on the HAstV-2 and HAstV-4 complete genomes.基于 HAstV-2 和 HAstV-4 全基因组的重组分析。
Infect Genet Evol. 2014 Mar;22:94-102. doi: 10.1016/j.meegid.2014.01.010. Epub 2014 Jan 22.
9
Norovirus infection in pediatric hematopoietic stem cell transplantation recipients: incidence, risk factors, and outcome.儿童造血干细胞移植受者诺如病毒感染：发生率、危险因素和结局。
Biol Blood Marrow Transplant. 2012 Dec;18(12):1883-9. doi: 10.1016/j.bbmt.2012.07.005. Epub 2012 Jul 10.
10
Sequence analysis of the human virome in febrile and afebrile children.发热和不发热儿童的人类病毒组序列分析。
PLoS One. 2012;7(6):e27735. doi: 10.1371/journal.pone.0027735. Epub 2012 Jun 13.