循环 CD34+ 阳性细胞上 B2 受体的表达与心肌梗死的结局。

Expression of B2 Receptor on Circulating CD34-Positive Cells and Outcomes of Myocardial Infarction.

机构信息

Department of Cardiology, Yi Ji Shan Hospital Affiliated to Wan Nan Medical College, China.

Key Laboratory of Non-Coding RNA Transformation Research of Anhui Higher Education Institution (Wan Nan Medical College), China.

出版信息

Dis Markers. 2019 Jul 8;2019:7816438. doi: 10.1155/2019/7816438. eCollection 2019.

DOI:10.1155/2019/7816438

PMID:31360266

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6644252/

Abstract

BACKGROUND

Bradykinin B2 receptor (B2R) is a widely expressed cell surface receptor. The relationship between B2R expression on circulating CD34+ cells and prognosis of myocardial infarction remains unknown.

METHODS

We analyzed the expression of B2R on circulating CD34-positive cells and plasma VEGF concentration in 174 myocardial infarction patients. All involved patients were divided into two groups: high B2R group and low B2R group according to the median B2R expression percentage. 48 months of follow-up was performed. The endpoints were heart failure and revascularization.

RESULTS

The plasma level of VEGF in the low B2R group is 67 ± 12 pg/mL, whereas the high B2R group has significantly elevated VEGF levels of 145 ± 27 pg/mL ( < 0.001). The concentration of VEGF has correlated with expression of B2R ( = 0.574, < 0.001). During the 48 months of follow-up, low expression of B2 receptor on circulating CD34-positive cells indicates the high incidence of heart failure (hazard ratio: 2.247; 95% confidence interval: 1.110-4.547; = 0.024) and revascularization (hazard ratio: 2.335; 95% confidence interval: 1.075-5.074; = 0.032). Kaplan-Meier survival analysis showed that the cumulative hazard of heart failure ( = 0.014) and revascularization ( = 0.032) has significant differences between low B2R and high B2R.

CONCLUSION

Low expression of B2R on circulating progenitor cells indicated the poor outcomes of myocardial infarction.

摘要

背景

缓激肽 B2 受体（B2R）是一种广泛表达的细胞表面受体。循环 CD34+细胞上 B2R 的表达与心肌梗死的预后之间的关系尚不清楚。

方法

我们分析了 174 例心肌梗死患者循环 CD34 阳性细胞上 B2R 的表达和血浆 VEGF 浓度。所有患者均根据 B2R 表达百分比的中位数分为高 B2R 组和低 B2R 组。进行了 48 个月的随访。终点是心力衰竭和血运重建。

结果

低 B2R 组的血浆 VEGF 水平为 67±12pg/ml，而高 B2R 组的 VEGF 水平显著升高，为 145±27pg/ml（<0.001）。VEGF 的浓度与 B2R 的表达相关（=0.574，<0.001）。在 48 个月的随访期间，循环 CD34 阳性细胞上 B2 受体的低表达表明心力衰竭（危险比：2.247；95%置信区间：1.110-4.547；=0.024）和血运重建（危险比：2.335；95%置信区间：1.075-5.074；=0.032）的发生率较高。Kaplan-Meier 生存分析显示，低 B2R 和高 B2R 之间心力衰竭（=0.014）和血运重建（=0.032）的累积危险有显著差异。