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母亲体重指数与婴儿先天性心脏病风险：剂量反应荟萃分析。

Maternal Body Mass Index and Risk of Congenital Heart Defects in Infants: A Dose-Response Meta-Analysis.

机构信息

School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China.

出版信息

Biomed Res Int. 2019 Jul 7;2019:1315796. doi: 10.1155/2019/1315796. eCollection 2019.

DOI:10.1155/2019/1315796
PMID:31360700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6642764/
Abstract

OBJECTIVE

The exact shape of the dose-response relationship between maternal body mass index (BMI) and the risk of congenital heart defects (CHDs) in infants has not been clearly defined yet. This study aims to further clarify the relationship between maternal obesity and the risk of CHDs in infants by an overall and dose-response meta-analysis.

METHODS

PubMed, Embase, and Web of Science databases were searched to identify all related studies. The studies were limited to human cohort or case-control studies in English language. Random-effect models and dose-response meta-analysis were used to synthesize the results. Heterogeneity, subgroup analysis, sensitivity analysis, and publication bias were also assessed.

RESULTS

Nineteen studies with 2,416,546 participants were included in our meta-analysis. Compared with the mothers with normal weight, the pooled relative risks (RRs) of infants with CHDs were 1.08 (95% CI=1.03-1.13) in overweight and 1.23 (95% CI=1.17-1.29) in obese mothers. According to the findings from the linear meta-analysis, we observed an increased risk of infants with CHDs (RR=1.07, 95% CI=1.06-1.08) for each 5 kg/m increase in maternal BMI. A nonlinear relationship between maternal BMI and risk of infants with CHDs was also found (=0.012).

CONCLUSION

The results from our meta-analysis indicate that increased maternal BMI is related to increased risk of CHDs in infants.

摘要

目的

母体体重指数（BMI）与婴儿先天性心脏病（CHD）风险之间的剂量-反应关系的确切形状尚未明确界定。本研究旨在通过全面和剂量-反应荟萃分析进一步阐明母体肥胖与婴儿 CHD 风险之间的关系。

方法

检索了 PubMed、Embase 和 Web of Science 数据库，以确定所有相关研究。这些研究仅限于英语的人类队列或病例对照研究。使用随机效应模型和剂量-反应荟萃分析来综合结果。还评估了异质性、亚组分析、敏感性分析和发表偏倚。

结果

我们的荟萃分析纳入了 19 项研究，共有 2416546 名参与者。与体重正常的母亲相比，超重母亲和肥胖母亲所生婴儿患 CHD 的合并相对风险（RR）分别为 1.08（95%CI=1.03-1.13）和 1.23（95%CI=1.17-1.29）。根据线性荟萃分析的结果，我们观察到母亲 BMI 每增加 5kg/m，婴儿患 CHD 的风险增加（RR=1.07，95%CI=1.06-1.08）。还发现母体 BMI 与婴儿患 CHD 的风险之间存在非线性关系（=0.012）。

结论

我们的荟萃分析结果表明，母亲 BMI 的增加与婴儿 CHD 的风险增加有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/915d437a77f8/BMRI2019-1315796.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/4fdefbf708d2/BMRI2019-1315796.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/2e83393a8dcb/BMRI2019-1315796.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/87479cab3271/BMRI2019-1315796.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/d5c49492d25d/BMRI2019-1315796.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/6dae876d25fa/BMRI2019-1315796.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/915d437a77f8/BMRI2019-1315796.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/4fdefbf708d2/BMRI2019-1315796.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/2e83393a8dcb/BMRI2019-1315796.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/87479cab3271/BMRI2019-1315796.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/d5c49492d25d/BMRI2019-1315796.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/6dae876d25fa/BMRI2019-1315796.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e97b/6642764/915d437a77f8/BMRI2019-1315796.006.jpg

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