Menon Sonia, Rodolfo Rossi, Akudibillah Gordon, Dusabimana Alfred, Harmon Stacy, Mabeya Hillary
International Centre for Reproductive Health (ICRH), Ghent University, De Pintelaan 185 P3, 9000 Ghent, Belgium.
Social Solutions International, Rockville, MD 20852, USA.
Gynecol Oncol Rep. 2019 Jul 4;29:64-69. doi: 10.1016/j.gore.2019.07.002. eCollection 2019 Aug.
In Africa, the HIV prevalence in rural areas has begun to reach levels estimated within urban settings, where women are also more at risk for both malaria and intestinal parasitic infections. The objective of this review is to assess whether concomitant infections with malaria and/or helminthic diseases have an impact on cervical disease progression in women on HAART. This scoping review was conducted in August 2018. To conduct this scoping review, we searched the relevant studies in electronic databases such as PUBMED, Global Health, EMBASE, CINAHL and SCOPUS published in the year between 1960 and 2018 using the following search terms HAART AND malaria OR Helminth and Female OR women. Eight studies qualified for this review. The literature underscores the need for women on HAART with multiple co-infections to use adjuncts to retain immune recovery and undetectable HIV viral load, to reduce risk of cervical disease progression. A trend for higher risk of CIN3+ in HIV+ women reporting recent malarial infection was observed in one study. Given the public health impact of synergistic interactions between malaria and helminthic infections in HIV/HPV co-infected women on HAART, it is urgent that these interactions are elucidated.
在非洲，农村地区的艾滋病毒流行率已开始达到城市地区的估计水平，而在城市地区，女性患疟疾和肠道寄生虫感染的风险也更高。本综述的目的是评估疟疾和/或蠕虫病的合并感染是否会对接受高效抗逆转录病毒治疗（HAART）的女性的宫颈疾病进展产生影响。这项范围综述于2018年8月进行。为进行此项范围综述，我们使用以下检索词“HAART AND malaria OR Helminth and Female OR women”在电子数据库如PUBMED、Global Health、EMBASE、CINAHL和SCOPUS中检索了1960年至2018年期间发表的相关研究。八项研究符合本综述要求。文献强调，对于患有多种合并感染且接受HAART治疗的女性，需要使用辅助药物来维持免疫恢复和使艾滋病毒病毒载量检测不到，以降低宫颈疾病进展的风险。在一项研究中观察到，报告近期感染疟疾的艾滋病毒阳性女性患高级别宫颈上皮内瘤变（CIN3+）的风险有升高趋势。鉴于疟疾和蠕虫感染之间的协同相互作用对接受HAART治疗的艾滋病毒/人乳头瘤病毒（HIV/HPV）合并感染女性的公共卫生影响，迫切需要阐明这些相互作用。
