Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
J Comp Eff Res. 2019 Jul;8(10):753-766. doi: 10.2217/cer-2019-0016. Epub 2019 Jul 30.
To compare efficacy between total gastrectomy (TG) and proximal gastrectomy (PG) for upper-third gastric cancer. PubMed, Embase and Cochrane library were searched to select suitable researches. Stata was used for meta-analysis including 5-year overall survival rate, recurrence rate, complication morbidities and serum nutritional levels. Ten retrospective English researches were contained. Our study showed no significant difference of 5-year overall survival rate, recurrence rate, reflux symptoms and anastomotic leakage. TG experienced longer operation time, more lymph nodes-retrieved number, more estimated blood loss and higher ileus, but less anastomotic stricture. PG showed advantages over TG in terms of serum nutritional levels. PG is more preferable to TG for treatment of upper-third gastric cancer.
为比较全胃切除术（TG）和近端胃切除术（PG）治疗胃上部癌的疗效。检索了 PubMed、Embase 和 Cochrane 图书馆以选择合适的研究。采用 Stata 进行荟萃分析，包括 5 年总生存率、复发率、并发症发病率和血清营养水平。包含 10 项回顾性英文研究。我们的研究显示，5 年总生存率、复发率、反流症状和吻合口漏的差异无统计学意义。TG 手术时间较长，淋巴结清扫数目较多，估计出血量较多，肠梗阻发生率较高，但吻合口狭窄发生率较低。PG 在血清营养水平方面优于 TG。PG 治疗胃上部癌优于 TG。
