Department of Immunotherapy, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou City 450008, China.
Immunotherapy. 2019 Sep;11(13):1087-1093. doi: 10.2217/imt-2019-0034. Epub 2019 Jul 30.
Pseudoprogression is a unique, uncommon phenomenon that often hints at good prognosis. To date, there has been no report of complete remission after pseudoprogression. Here, we report successful treatment of metastatic renal clear cell cancer, using anti-PD-1 antibodies combined with autologous RetroNectin-activated cytokine-induced killer cells, in two patients who were failed to multitargeted kinase inhibitors. After early pseudoprogression, complete remission was achieved. At present, one patient has stopped therapy for about 1.5 years and is still disease free.
假性进展是一种独特且不常见的现象，常提示预后良好。迄今为止，尚无假性进展后完全缓解的报道。在此，我们报告了两例接受抗 PD-1 抗体联合自体 RetroNectin 激活细胞因子诱导的杀伤细胞治疗失败的转移性肾透明细胞癌患者，这些患者对多靶点激酶抑制剂治疗无效。在早期假性进展后，达到完全缓解。目前，一名患者已停药约 1.5 年，仍无疾病进展。
