金/血清白蛋白复合物的结构表征
Structural Characterization of a Gold/Serum Albumin Complex.
作者信息
Pratesi Alessandro, Cirri Damiano, Fregona Dolores, Ferraro Giarita, Giorgio Anna, Merlino Antonello, Messori Luigi
机构信息
Laboratory of Metals in Medicine (MetMed), Department of Chemistry "U. Schiff" , University of Florence , via della Lastruccia 3 , 50019 Sesto Fiorentino , Italy.
Department of Chemical Sciences , University of Padova , via Marzolo 1 , 35131 Padova , Italy.
出版信息
Inorg Chem. 2019 Aug 19;58(16):10616-10619. doi: 10.1021/acs.inorgchem.9b01900. Epub 2019 Jul 30.
The medicinal gold(III) dithiocarbamato complex AuL forms a stable adduct with bovine serum albumin. The crystal structure reveals that a single gold(I) center is bound to Cys34, with the dithiocarbamato ligand being released. To the best of our knowledge, this is the first structure for a gold adduct of serum albumin.
药用二硫代氨基甲酸金（III）配合物AuL与牛血清白蛋白形成稳定的加合物。晶体结构表明，单个金（I）中心与半胱氨酸34结合，二硫代氨基甲酸盐配体被释放。据我们所知，这是血清白蛋白金加合物的首个结构。
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